Grover G J, Weiss H R
Proc Soc Exp Biol Med. 1985 Nov;180(2):270-6. doi: 10.3181/00379727-180-42175.
The purpose of this study was to determine if differences in the cardioprotective abilities of ibuprofen and indomethacin were due to their differing abilities to alter the O2 supply/consumption ratio in the ischemic myocardium. Experiments were done on 21 anesthetized open-chest rabbits. Regional flow (using radioactive microspheres), O2 extraction, O2 consumption, and O2 supply/consumption ratio were determined 1 hr after occlusion of the left anterior descending coronary artery in controls and animals given iv 10 mg/kg ibuprofen or iv 3 mg/kg indomethacin. Myocardial blood flow was depressed in the occluded region compared to the nonoccluded region after occlusion for all treatments. O2 extraction in the occluded region was elevated compared to the nonoccluded region for all treatments after occlusion. No differences in O2 consumption were noted between any treatment within the occluded or nonoccluded regions. The O2 supply/consumption ratio was lower in the occluded region compared to the nonoccluded region for all treatments. No differences in this ratio were noted between any treatment. Thus, the effects of indomethacin or ibuprofen on ischemia are not related to acute changes in myocardial O2 supply/consumption balance.
本研究的目的是确定布洛芬和吲哚美辛心脏保护能力的差异是否归因于它们改变缺血心肌氧供/氧耗比的能力不同。对21只麻醉开胸兔进行了实验。在对照组以及静脉注射10mg/kg布洛芬或静脉注射3mg/kg吲哚美辛的动物中，于左冠状动脉前降支闭塞1小时后测定局部血流量（使用放射性微球）、氧摄取、氧消耗和氧供/氧耗比。与非闭塞区域相比，所有处理在闭塞后闭塞区域的心肌血流量均降低。与非闭塞区域相比，所有处理在闭塞后闭塞区域的氧摄取均升高。在闭塞或非闭塞区域内，任何处理之间的氧消耗均无差异。与非闭塞区域相比，所有处理在闭塞区域的氧供/氧耗比均较低。任何处理之间该比值均无差异。因此，吲哚美辛或布洛芬对缺血的影响与心肌氧供/氧耗平衡的急性变化无关。
