硬皮病Tsk小鼠模型中的肥大细胞及其脱颗粒作用

Mast cells and their degranulation in the Tsk mouse model of scleroderma.

作者信息

Walker M, Harley R, Maize J, DeLustro F, LeRoy E C

出版信息

Proc Soc Exp Biol Med. 1985 Nov;180(2):323-8. doi: 10.3181/00379727-180-42183.

Abstract

The Tsk mouse is a genetically transmitted example of cutaneous fibrosis which has been compared with human scleroderma. During a systematic histopathological study of the Tsk mouse, both an increased number and an increased proportion of degranulated mast cells were observed. The consistent association of mast cells and fibrosis in scleroderma, graft-vs-host reactions (GVHR), and now the Tsk mouse raises the question of a pathogenetic role for mast cells in fibrotic disorders in general.

摘要

Tsk小鼠是一种遗传性皮肤纤维化模型，已被用于与人类硬皮病进行比较研究。在对Tsk小鼠进行系统的组织病理学研究过程中，观察到脱颗粒肥大细胞的数量增加且比例上升。肥大细胞与硬皮病、移植物抗宿主反应（GVHR）中的纤维化始终存在关联，如今在Tsk小鼠中也是如此，这就提出了一个问题，即肥大细胞在一般纤维化疾病中是否具有致病作用。