系统性硬化症（硬皮病）中的抗IgE自身抗体。
Anti-IgE autoantibodies in systemic sclerosis (scleroderma).
作者信息
Kaufman L D, Gruber B L, Marchese M J, Seibold J R
机构信息
Department of Medicine, State University of New York, Stony Brook 11794-8161.
出版信息
Ann Rheum Dis. 1989 Mar;48(3):201-5. doi: 10.1136/ard.48.3.201.
An enzyme immunoassay was used to determine the prevalence of anti-IgE auto-antibodies in 66 patients with systemic sclerosis (scleroderma) stratified according to extent and duration of disease. Serum IgG anti-IgE antibodies were detected in 14 (21%) patients and IgM anti-IgE antibodies in nine (14%) patients. The overall prevalence of IgG or IgM isotypes was 21/66, (32%). Anti-IgE autoantibodies were not found in six patients with undifferentiated connective tissue disease or two patients with eosinophilic fasciitis. Attempts to demonstrate histamine release from basophils in vitro by using serum samples containing high titre anti-IgE antibody were unsuccessful. By multivariate analysis the presence of anti-IgE antibody was not associated with duration of systemic sclerosis; extent of scleroderma; specific visceral features, including heart, lung, renal, and gastrointestinal involvement; or mortality.
采用酶免疫测定法，对66例根据疾病程度和病程分层的系统性硬化症（硬皮病）患者进行抗IgE自身抗体患病率的测定。在14例（21%）患者中检测到血清IgG抗IgE抗体，9例（14%）患者中检测到IgM抗IgE抗体。IgG或IgM同种型的总体患病率为21/66（32%）。在6例未分化结缔组织病患者或2例嗜酸性筋膜炎患者中未发现抗IgE自身抗体。使用含有高滴度抗IgE抗体的血清样本在体外诱导嗜碱性粒细胞释放组胺的尝试未成功。多因素分析显示，抗IgE抗体的存在与系统性硬化症的病程、硬皮病的范围、特定内脏特征（包括心脏、肺部、肾脏和胃肠道受累情况）或死亡率无关。
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