Hecker V D
Acta Histochem. 1977;58(1):105-24.
For human mammary and ovarian carcinomas and transplantation tumours of rats clear hints found for an enzymatic-lytic effects of infiltrating tumour cells as a premise of the invasive tumour growth. In contrast in malignant melanomas there is no functional sign for a specific enzymatic-lytic effect of the living tumour cells to the surrounding tissue. In the mamma carinomas and ovarian carcinomas infiltratively growing tumour districts were characterized by an increased activity of the NADH-D, LDH, G-6-P-DH, IDH, MDH, SPase, UE, LAP and beta-GD. The transplantation tumours showed a high number of tumour cells with a high leucine amino-peptidase- and beta-glucuronidase-activity in a middle zone that was localized under the tumour edge district. The increased activity of the LAP and beta-GD found in the infiltration zone of the tumours is considered as an demonstration of a strong proteolytic activity of the tumour cells. The findings are discussed in the aspect of the invasive tumour growth.
对于人类乳腺癌和卵巢癌以及大鼠移植瘤，发现浸润性肿瘤细胞具有酶解作用的明确迹象，这是肿瘤侵袭性生长的前提。相比之下，在恶性黑色素瘤中，没有迹象表明活的肿瘤细胞对周围组织具有特定的酶解作用。在乳腺癌和卵巢癌中，浸润性生长的肿瘤区域的特征是NADH-D、LDH、G-6-P-DH、IDH、MDH、SPase、UE、LAP和β-GD的活性增加。移植瘤在位于肿瘤边缘区下方的中间区域显示出大量具有高亮氨酸氨肽酶和β-葡萄糖醛酸酶活性的肿瘤细胞。在肿瘤浸润区发现的LAP和β-GD活性增加被认为是肿瘤细胞强大蛋白水解活性的证明。从肿瘤侵袭性生长的角度对这些发现进行了讨论。
