Hynes M D, Langer D H, Hymson D L, Pearson D V, Fuller R W
Pharmacol Biochem Behav. 1985 Sep;23(3):445-8. doi: 10.1016/0091-3057(85)90019-x.
Spontaneously hypertensive rats (SHR) exhibit a significantly higher level of spontaneous locomotor activity than age-matched normotensive controls (WKY). The direct-acting dopamine agonists, apomorphine and pergolide, produced a biphasic effect on locomotor activity levels in normotensive controls. Low doses of these agonists decreased activity levels, while higher doses of these agonists dramatically stimulated activity. In marked contrast to these results was the effect observed in the SHR, in which these agonists at all doses tested decreased activity. Amphetamine, a dopamine releaser, stimulated activity levels in both the WKY and SHR; however, the magnitude of the increase was somewhat attenuated in the SHR.
自发性高血压大鼠（SHR）比年龄匹配的正常血压对照大鼠（WKY）表现出显著更高水平的自发运动活性。直接作用的多巴胺激动剂阿扑吗啡和培高利特对正常血压对照大鼠的运动活性水平产生双相效应。这些激动剂的低剂量降低了活性水平，而高剂量则显著刺激了活性。与这些结果形成鲜明对比的是在SHR中观察到的效应，在SHR中，所有测试剂量的这些激动剂都降低了活性。安非他明是一种多巴胺释放剂，它刺激了WKY和SHR的活性水平；然而，SHR中活性增加的幅度有所减弱。
