Kang Haobo, Sun Yubo, Fang Zhenchi, Ding Weijie, Bai Tianyuan, Yang Kun, Jiang Dongbo
Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Xi'an 710032, Shaanxi, China.
Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Xi'an 710032, Shaanxi, China; The Key Laboratory of Bio-Hazard Damage and Prevention Medicine, Basic Medicine School, Air-Force Medical University (The Fourth Military Medical University), Xi'an 710032, China.
Int J Biol Macromol. 2025 Jul;318(Pt 1):145010. doi: 10.1016/j.ijbiomac.2025.145010. Epub 2025 Jun 5.
Apparently, mRNA vaccines have played a pivotal role in curbing the further spread of COVID-19. However, their deployment has been accompanied by reports of adverse events (AEs), including cardiovascular and neurological symptoms. The comprehensive review proposes a conceptual framework to better characterize AEs, elucidate the underlying mechanisms, and outline therapeutic strategies. It also profiles AEs into a three-axe mechanism classification: host susceptibility, delivery system interactions, and mRNA component immunogenicity, thereby advancing current understanding of their etiology. Finally, the analysis integrates these axes with critical perspectives - mRNA molecular design, platform-specific toxicity, and human nature - to provide a comprehensive roadmap for addressing above issues.
显然，mRNA疫苗在遏制新冠病毒的进一步传播中发挥了关键作用。然而，其应用伴随着不良事件（AE）的报告，包括心血管和神经症状。这项全面综述提出了一个概念框架，以更好地表征不良事件、阐明潜在机制并概述治疗策略。它还将不良事件归纳为一种三轴机制分类：宿主易感性、递送系统相互作用和mRNA成分免疫原性，从而推进了目前对其病因的理解。最后，该分析将这些轴与关键观点——mRNA分子设计、平台特异性毒性和人性——相结合，以提供一个解决上述问题的全面路线图。
