Borcherding Sydney, Wood Matthew D, Pinni Sai L, Schellhardt Lauren, Faust Anne E, Behun Marissa N, Skillen Clint, Chawla Pooja, Kulkarni Mangesh, Demeter Elena A, Miller Andrew D, Mahan Mark A, Brown Bryan N, Soletti Lorenzo
Renerva, Inc., Pittsburgh, PA, USA.
Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
NPJ Regen Med. 2025 Jun 7;10(1):29. doi: 10.1038/s41536-025-00416-z.
Neuroma following nerve injury and/or amputation is a debilitating condition with significant impacts on quality of life. Several approaches exist to prevent or treat neuroma and/or reduce associated pain; however, these approaches are not consistently effective, facile, or widely accessible. The present study characterizes a xenogeneic nerve cap graft device (NCGD) composed of decellularized porcine nerve. The NCGD was assessed for its ability to inhibit nerve growth, neuroma formation, and pain in rodent models of sciatic neurectomy and tibial neuroma transposition. The NCGD provided a neuroinhibitory substrate that abated and interrupted nerve growth within 5 mm of the nerve stump and was progressively remodeled into healthy host-derived tissue. The NCGD also resulted in a 3.5-fold reduction in evoked pain and a decrease in pain-associated markers at the dorsal root ganglia. These results suggest that the NCGD may provide a simple and widely accessible alternative for prophylactic treatment of symptomatic neuroma.
神经损伤和/或截肢后形成的神经瘤是一种使人衰弱的病症，对生活质量有重大影响。目前有几种方法可用于预防或治疗神经瘤和/或减轻相关疼痛；然而，这些方法并非始终有效、简便易行或广泛可用。本研究对一种由脱细胞猪神经组成的异种神经帽移植装置（NCGD）进行了表征。在坐骨神经切除术和胫神经瘤移位的啮齿动物模型中，评估了NCGD抑制神经生长、神经瘤形成和疼痛的能力。NCGD提供了一种神经抑制性基质，可在神经残端5毫米范围内减弱并中断神经生长，并逐渐重塑为健康的宿主来源组织。NCGD还使诱发疼痛降低了3.5倍，并减少了背根神经节处与疼痛相关的标志物。这些结果表明，NCGD可能为有症状神经瘤的预防性治疗提供一种简单且广泛可用的替代方法。
