Shan Zhu, Manan Sehrish, Jiang Bo, Wang Peng, Bakadia Bianza Moise, Wu Wenjuan, Jin Yongcan
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China; Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China.
State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Int J Biol Macromol. 2025 Jul;318(Pt 3):144976. doi: 10.1016/j.ijbiomac.2025.144976. Epub 2025 Jun 6.
Bacterial infections remain a major public health concern, highlighting the need for effective antimicrobial materials, especially in wound care. Antimicrobial hydrogels have emerged as promising solutions due to their unique properties, such as high strength, injectability, biocompatibility, and the ability to control drug release. Recently, lignin, as an abundant and renewable biomass component, has shown great potential in biomedicine due to its unique bioactivity, good biocompatibility, and designable structure. Considering the significant progress of lignin-containing antimicrobial hydrogels for wound healing, this article attempts to review the cutting-edge research on various types of lignin-containing antimicrobial hydrogels aiming to provide a deeper understanding of the structure-property-function correlation and the antibacterial mechanism of these hydrogels. The structural characteristics of lignin and hydrogels endow them with multifunctionality, enabling their application as wound dressings. This demonstrates the complete chain of logic from structural design to performance modulation to application. The prospects of lignin-containing hydrogels for monitoring wound dynamically, broadening the antibacterial spectrum, measuring and controlling antibacterial efficacy, expanding the application range, and promoting clinical safety are also highlighted. The integration of these advancements can address the evolving challenges in wound care, making lignin-containing hydrogels a promising solution for next-generation wound dressings.
细菌感染仍然是一个重大的公共卫生问题，这凸显了对有效抗菌材料的需求，尤其是在伤口护理方面。抗菌水凝胶因其独特的性能，如高强度、可注射性、生物相容性以及控制药物释放的能力，已成为有前景的解决方案。最近，木质素作为一种丰富的可再生生物质成分，由于其独特的生物活性、良好的生物相容性和可设计的结构，在生物医学领域显示出巨大潜力。鉴于含木质素的抗菌水凝胶在伤口愈合方面取得的显著进展，本文试图综述各类含木质素的抗菌水凝胶的前沿研究，旨在更深入地了解这些水凝胶的结构 - 性能 - 功能关系及其抗菌机制。木质素和水凝胶的结构特征赋予它们多功能性，使其能够用作伤口敷料。这展示了从结构设计到性能调控再到应用的完整逻辑链。还强调了含木质素水凝胶在动态监测伤口、拓宽抗菌谱、测量和控制抗菌效果、扩大应用范围以及提高临床安全性方面的前景。这些进展的整合可以应对伤口护理中不断演变的挑战，使含木质素水凝胶成为下一代伤口敷料的有前景的解决方案。
