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From controversy to clarity: reimagining the role of CDK4/6 inhibitors in the adjuvant setting- a number needed to treat perspective.从争议到明晰:重新审视CDK4/6抑制剂在辅助治疗中的作用——基于需治数的视角
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CDK4/6 inhibitors as adjuvant treatment for hormone receptor-positive, HER2-negative early breast cancer: a systematic review and meta-analysis.CDK4/6 抑制剂作为激素受体阳性、HER2 阴性早期乳腺癌的辅助治疗:系统评价和荟萃分析。
ESMO Open. 2021 Apr;6(2):100091. doi: 10.1016/j.esmoop.2021.100091. Epub 2021 Mar 18.
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Using bioinformatics and artificial intelligence to map the cyclin-dependent kinase 4/6 inhibitor biomarker landscape in breast cancer.利用生物信息学和人工智能绘制乳腺癌中细胞周期蛋白依赖性激酶4/6抑制剂生物标志物图谱。
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Influence of ethnicity on cyclin-dependent kinase inhibitor efficacy and toxicity: A systematic review and meta-analysis.种族对细胞周期蛋白依赖性激酶抑制剂疗效和毒性的影响:一项系统评价和荟萃分析。
Breast. 2025 Feb;79:103833. doi: 10.1016/j.breast.2024.103833. Epub 2024 Nov 4.

本文引用的文献

1
Why We Do Not Recommend That Women With Breast Cancer Receive Adjuvant Treatment With a CDK4/6 Inhibitor.为何我们不建议乳腺癌女性接受CDK4/6抑制剂辅助治疗。
J Clin Oncol. 2025 Aug;43(22):2456-2460. doi: 10.1200/JCO-24-02683. Epub 2025 Apr 14.
2
Ribociclib plus Endocrine Therapy in Early Breast Cancer.来曲唑联合内分泌治疗早期乳腺癌。
N Engl J Med. 2024 Mar 21;390(12):1080-1091. doi: 10.1056/NEJMoa2305488.
3
Informative censoring - a neglected cause of bias in oncology trials.信息删失——肿瘤学试验中一个被忽视的偏倚原因。
Nat Rev Clin Oncol. 2020 Jun;17(6):327-328. doi: 10.1038/s41571-020-0368-0.
4
Cyclin-dependent kinase 4 and 6 inhibitors for hormone receptor-positive breast cancer: past, present, and future.细胞周期蛋白依赖性激酶 4 和 6 抑制剂治疗激素受体阳性乳腺癌:过去、现在和未来。
Lancet. 2020 Mar 7;395(10226):817-827. doi: 10.1016/S0140-6736(20)30165-3.
5
Palbociclib with Letrozole in Postmenopausal Women with ER+/HER2- Advanced Breast Cancer: Hematologic Safety Analysis of the Randomized PALOMA-2 Trial.帕博西尼联合来曲唑治疗绝经后激素受体阳性、人表皮生长因子受体 2 阴性晚期乳腺癌的随机 PALOMA-2 试验的血液学安全性分析。
Oncologist. 2019 Dec;24(12):1514-1525. doi: 10.1634/theoncologist.2019-0019. Epub 2019 Jun 19.
6
The Genetic Landscape and Clonal Evolution of Breast Cancer Resistance to Palbociclib plus Fulvestrant in the PALOMA-3 Trial.帕博西尼联合氟维司群治疗乳腺癌耐药的遗传特征和克隆进化:PALOMA-3 临床试验研究。
Cancer Discov. 2018 Nov;8(11):1390-1403. doi: 10.1158/2159-8290.CD-18-0264. Epub 2018 Sep 11.
7
Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials.芳香酶抑制剂与他莫昔芬治疗早期乳腺癌:随机试验的患者水平荟萃分析。
Lancet. 2015 Oct 3;386(10001):1341-1352. doi: 10.1016/S0140-6736(15)61074-1. Epub 2015 Jul 23.
8
Choosing sensitivity analyses for randomised trials: principles.随机试验敏感性分析的选择:原则。
BMC Med Res Methodol. 2014 Jan 24;14:11. doi: 10.1186/1471-2288-14-11.
9
Trastuzumab--mechanism of action and use in clinical practice.曲妥珠单抗——作用机制及临床应用
N Engl J Med. 2007 Jul 5;357(1):39-51. doi: 10.1056/NEJMra043186.
10
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.早期乳腺癌化疗和激素治疗对复发及15年生存率的影响:随机试验综述
Lancet. 2005;365(9472):1687-717. doi: 10.1016/S0140-6736(05)66544-0.

From controversy to clarity: reimagining the role of CDK4/6 inhibitors in the adjuvant setting- a number needed to treat perspective.

作者信息

Orlandi Armando

机构信息

Comprehensive Cancer Center, UOC Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.

出版信息

J Cancer Res Clin Oncol. 2025 Jun 9;151(6):185. doi: 10.1007/s00432-025-06229-3.

DOI:10.1007/s00432-025-06229-3
PMID:40484902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12146219/
Abstract
摘要