Karabulut Mustafa, Kutlu Sevgi, Viechtbauer Wolfgang, Melliti Ali, Meço Cem, Mohamad Alfarghal, Özgirgin Osman Nuri, Bhandari Anita, Kingma Herman, van de Berg Raymond
Department of Otorhinolaryngology and Head and Neck Surgery, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands.
Department of Audiology, Faculty of Health Sciences, Ankara University, Ankara, Türkiye.
Clin Exp Otorhinolaryngol. 2025 Jun 9. doi: 10.21053/ceo.2025-00030.
To systematically investigate the co-occurrence of otologic disorders and benign paroxysmal positional vertigo (BPPV).
PubMed and Web of Science.
All original studies in English, from full-text clinical trials to case reports, involving participants ≥18 years old, were included. Two groups of article were identified: Group 1) studies reporting co-occurring otologic disorders in BPPV patients; Group 2) studies reporting co-occurring BPPV in patients with otologic disorders. The frequency of each condition was analyzed using descriptive statistics. Meta-analyses were performed using a random-effects model to estimate overall prevalence in both groups.
A total of 3407 studies were retrieved of which 68 articles were included in the analysis. In Group 1, 11.4% of BPPV patients (932/8157) had co-occurring otologic disorders (19 studies). The most commonly reported conditions were sudden sensorineural hearing loss (11.9%) and acute unilateral vestibulopathy/vestibular neuritis (5.0%). Meta-analyses showed pooled prevalences of 11.8% (95% CI: 3.1%- 35.7%) for sudden sensorineural hearing loss and 6.5% (95% CI: 3.7%-11.2%) for acute unilataral vestibulopathy/vestibular neuritis. In Group 2, 9.7% of patients with otologic disorders (1106/11457) had co-occurring BPPV (49 studies). Menière's disease was the most frequently reported disorder that resulted in co-occurring BPPV (10.2%). Meta-analyses showed pooled prevalences of 10.4% (95% CI: 6.2%-16.8%) for acute unilateral vestibulopathy/vestibular neuritis and 9.1% (95% CI: 4%-19.1%) for Menière's disease.
The co-occurrence of otologic disorders and BPPV are prevalent. These findings demonstrate the need for mutual screening of BPPV and otologic disorders. Furthermore, these findings might help understanding the etiologies underlying BPPV.
系统研究耳科疾病与良性阵发性位置性眩晕（BPPV）的共现情况。
PubMed和科学网。
纳入所有英文原创研究，从全文临床试验到病例报告，研究对象年龄≥18岁。确定了两组文章：第1组）报告BPPV患者中同时存在耳科疾病的研究；第2组）报告耳科疾病患者中同时存在BPPV的研究。使用描述性统计分析每种情况的发生频率。采用随机效应模型进行Meta分析，以估计两组的总体患病率。
共检索到3407项研究，其中68篇文章纳入分析。在第1组中，11.4%的BPPV患者（932/8157）同时存在耳科疾病（19项研究）。最常报告的情况是突发性感音神经性听力损失（11.9%）和急性单侧前庭病变/前庭神经炎（5.0%）。Meta分析显示，突发性感音神经性听力损失的合并患病率为11.8%（95%CI：3.1%-35.7%），急性单侧前庭病变/前庭神经炎的合并患病率为6.5%（95%CI：3.7%-11.2%）。在第2组中，9.7%的耳科疾病患者（1106/11457）同时存在BPPV（49项研究）。梅尼埃病是导致同时发生BPPV的最常报告的疾病（10.2%）。Meta分析显示，急性单侧前庭病变/前庭神经炎的合并患病率为10.4%（95%CI：6.2%-16.8%），梅尼埃病的合并患病率为9.1%（95%CI：4%-19.1%）。
耳科疾病与BPPV的共现情况很普遍。这些发现表明需要对BPPV和耳科疾病进行相互筛查。此外，这些发现可能有助于理解BPPV的潜在病因。
