Jia Yiyue, Lacombe Mathilde, Muller Catherine, Milhas Delphine
Équipe Labellisée Ligue Nationale contre le Cancer, Institut de Pharmacologie et de Biologie Structurale, CNRS/Université de Toulouse UMR, Toulouse, France.
Adipocyte. 2025 Dec;14(1):2508885. doi: 10.1080/21623945.2025.2508885. Epub 2025 Jun 9.
Adipose tissue (AT), one of the largest endocrine tissues in the human body, is an important site for the storage and production of steroid hormones. In particular, AT's capacity to produce androgens could enable it to have a regulatory role in local or general hormone homoeostasis. The links between obesity, polycystic ovary syndrome (PCOS), metabolic disorders, and hormonal balance emphasise the importance of understanding the intricate relationships between AT and androgen dynamics within AT. This review, focusing on androgen metabolism, summarises the androgen profile in white adipose tissue (WAT) and brown adipose tissue (BAT) of humans and animal models, along with the androgen-metabolising enzymes present in WAT, and explores the role of androgens on AT physiology.
脂肪组织(AT)是人体最大的内分泌组织之一,是类固醇激素储存和产生的重要场所。特别是,AT产生雄激素的能力使其能够在局部或全身激素稳态中发挥调节作用。肥胖、多囊卵巢综合征(PCOS)、代谢紊乱和激素平衡之间的联系强调了了解AT与AT内雄激素动态之间复杂关系的重要性。本综述聚焦于雄激素代谢,总结了人类和动物模型白色脂肪组织(WAT)和棕色脂肪组织(BAT)中的雄激素谱,以及WAT中存在的雄激素代谢酶,并探讨了雄激素对AT生理学的作用。