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基底动脉穿支动脉瘤破裂:治疗神经外科医生的噩梦。

Ruptured Basilar Artery Perforator Aneurysm: Nightmare of a Treating Neurosurgeon.

作者信息

Sarma Pragyan, Agrawal Atul, Sharma Amit Kumar

机构信息

Department of Neurosurgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

出版信息

Asian J Neurosurg. 2025 Mar 6;20(2):322-329. doi: 10.1055/s-0045-1804999. eCollection 2025 Jun.

DOI:10.1055/s-0045-1804999
PMID:40485783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12136949/
Abstract

Subarachnoid hemorrhage (SAH) resulting from rupture of basilar artery perforator aneurysm (BAPA) is a neurological rarity. With increased awareness and advancements in imaging modalities, they are now more frequently detected. However, concerns regarding their suboptimal treatment and lack of proper analysis still exist. We are hereby reporting our experience of treating this entity in a small cohort.  It is a retrospective study of all the cases of SAH resulting from rupture of BAPA, which were treated by the same surgical team. Demographic data, treatment characteristics, and follow-up data of our cases along with published literature were studied.  Our cohort comprised of five patients (mean age 55 years). Three cases were treated with flow diverter alone and the rest underwent flow diverter and overlapping stent placement. Initial diagnostic cerebral angiography (digital subtraction angiography) was negative in three of them. There was one mortality and favorable outcome was encountered in the remaining cases. All of them demonstrated complete occlusion of the aneurysm in follow-up.  Following treatment, all the cases demonstrated complete angiographic occlusion of the aneurysm. In available literature, studies have small sample sizes. Future randomized studies in a larger cohort and proper reporting and analysis of outcomes will help us formulating a treatment protocol for BAPA.

摘要

基底动脉穿支动脉瘤(BAPA)破裂导致的蛛网膜下腔出血(SAH)是一种罕见的神经系统疾病。随着认识的提高和成像技术的进步,现在对其检测更为频繁。然而,关于其治疗效果欠佳以及缺乏恰当分析的问题仍然存在。在此,我们报告我们在一个小队列中治疗该疾病的经验。

这是一项对所有由BAPA破裂导致SAH且由同一手术团队治疗的病例的回顾性研究。我们研究了病例的人口统计学数据、治疗特征、随访数据以及已发表的文献。

我们的队列包括5名患者(平均年龄55岁)。3例仅接受了血流导向装置治疗,其余患者接受了血流导向装置和重叠支架置入术。其中3例最初的诊断性脑血管造影(数字减影血管造影)结果为阴性。有1例死亡,其余病例预后良好。所有患者在随访中均显示动脉瘤完全闭塞。

治疗后,所有病例的动脉瘤在血管造影上均显示完全闭塞。在现有文献中,研究的样本量较小。未来在更大队列中进行的随机研究以及对结果的恰当报告和分析将有助于我们制定BAPA的治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c8/12136949/670a37e51fc9/10-1055-s-0045-1804999-i2460013-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c8/12136949/ce478b1177f2/10-1055-s-0045-1804999-i2460013-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c8/12136949/a2b40d19b9f4/10-1055-s-0045-1804999-i2460013-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c8/12136949/670a37e51fc9/10-1055-s-0045-1804999-i2460013-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c8/12136949/ce478b1177f2/10-1055-s-0045-1804999-i2460013-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c8/12136949/a2b40d19b9f4/10-1055-s-0045-1804999-i2460013-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c8/12136949/670a37e51fc9/10-1055-s-0045-1804999-i2460013-3.jpg

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本文引用的文献

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A giant basilar artery perforator aneurysm.一个巨大的基底动脉穿支动脉瘤。
Radiol Case Rep. 2022 Jan 14;17(3):911-913. doi: 10.1016/j.radcr.2021.12.034. eCollection 2022 Mar.
2
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Clin Neuroradiol. 2022 Sep;32(3):783-789. doi: 10.1007/s00062-021-01133-y. Epub 2022 Jan 20.
3
Endovascular electrothrombosis: A promising alternative for basilar artery perforator aneurysm treatment.
血管内电血栓形成:基底动脉穿支动脉瘤治疗的一种有前途的替代方法。
Interv Neuroradiol. 2021 Aug;27(4):511-515. doi: 10.1177/1591019920987913. Epub 2021 Jan 12.
4
Comparison between stenting and conservative management of posterior circulation perforator aneurysms: Systematic review and case series.支架置入与保守治疗后循环穿支动脉瘤的对比:系统评价和病例系列。
Neuroradiology. 2021 May;63(5):639-651. doi: 10.1007/s00234-020-02618-2. Epub 2021 Jan 6.
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A systematic review of non-trunk basilar perforator aneurysms: is it worth chasing the small fish?非脑干基底动脉穿支动脉瘤的系统评价:值得去追捕小鱼吗?
J Neurointerv Surg. 2020 Apr;12(4):412-416. doi: 10.1136/neurintsurg-2019-015311. Epub 2019 Oct 9.
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Subarachnoid haemorrhage with negative initial neurovascular imaging: a systematic review and meta-analysis.蛛网膜下腔出血初始神经血管影像学检查为阴性:系统评价和荟萃分析。
Acta Neurochir (Wien). 2019 Oct;161(10):2013-2026. doi: 10.1007/s00701-019-04025-w. Epub 2019 Aug 13.
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Acutely Ruptured Intracranial Aneurysms Treated with Flow-Diverter Stents: A Systematic Review and Meta-Analysis.急性破裂颅内动脉瘤采用血流导向装置治疗的系统评价和荟萃分析。
AJNR Am J Neuroradiol. 2018 Sep;39(9):1669-1675. doi: 10.3174/ajnr.A5730. Epub 2018 Jul 26.
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