佐匹克隆依赖：一例报告。
Dependence on zopiclone: a case report.
作者信息
Guo Nana, Zhou Xuhui
机构信息
School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Department of Addiction Medicine, Hunan Institute of Mental Health, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, Hunan, China.
出版信息
Front Psychiatry. 2025 May 23;16:1592065. doi: 10.3389/fpsyt.2025.1592065. eCollection 2025.
BACKGROUND
Zopiclone, a cyclopyrrolone derivative, is commonly employed for the short-term treatment of different types of insomnia. In comparison to benzodiazepines, Zopiclone appears to have a lower risk of abuse potential and withdrawal symptoms. Nevertheless, as the use of Zopiclone has increased, reports of abuse and dependence have begun to surface in the literature.
CASE PRESENTATION
This case report describes a 43-year-old male patient who has been taking zopiclone for 12 years, with a maximum daily dose of 112.5 mg. Two days after discontinuing the medication, the patient experienced withdrawal symptoms such as palpitations, sweating, irritability, hallucinations, and impulsive behavior, which resulted in his admission to a psychiatric hospital. After 17 days of treatment with diazepam, quetiapine fumarate, magnesium valproate, and trazodone hydrochloride, the patient's withdrawal symptoms alleviated, sleep quality improved, and medication cravings decreased.
CONCLUSION
Similar to benzodiazepines, Zopiclone may also result in abuse and dependency issues. Therefore, when prescribing Zopiclone, physicians must be fully aware of it.
背景
佐匹克隆是一种环吡咯酮衍生物，常用于短期治疗不同类型的失眠症。与苯二氮䓬类药物相比，佐匹克隆似乎具有较低的滥用可能性和戒断症状风险。然而，随着佐匹克隆使用量的增加，文献中开始出现关于滥用和依赖的报道。
病例介绍
本病例报告描述了一名43岁男性患者，他服用佐匹克隆已达12年，最大日剂量为112.5毫克。停药两天后，患者出现心悸、出汗、易怒、幻觉和冲动行为等戒断症状，导致他入住精神病院。经过17天使用地西泮、富马酸喹硫平、丙戊酸镁和盐酸曲唑酮治疗后，患者的戒断症状得到缓解，睡眠质量改善，对药物的渴望减少。
结论
与苯二氮䓬类药物类似，佐匹克隆也可能导致滥用和依赖问题。因此，在开具佐匹克隆处方时，医生必须充分意识到这一点。
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