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FGFR1 inhibition by carvacrol: A novel strategy for oral squamous cell carcinoma therapy.

作者信息

Xiang Shuzhen, Zhang Hongyan, Wang Qian, Fan Jiajia, Jia Shiheng, Zhang Lan, Ma Wei, Liu Minda, Li Yanshu, Dai Wei

机构信息

Department of Oral Maxillofacial-Head and Neck Surgery, School of Stomatology, China Medical University, Oral Diseases Laboratory of Liaoning, Shenyang, Liaoning 110000, China.

Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, China.

出版信息

Genes Dis. 2024 Dec 4;12(5):101479. doi: 10.1016/j.gendis.2024.101479. eCollection 2025 Sep.

DOI:10.1016/j.gendis.2024.101479
PMID:40485977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12142515/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c606/12142515/6192656fb616/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c606/12142515/6192656fb616/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c606/12142515/6192656fb616/gr1.jpg

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1
FGFR1 inhibition by carvacrol: A novel strategy for oral squamous cell carcinoma therapy.香芹酚抑制FGFR1：口腔鳞状细胞癌治疗的新策略。
Genes Dis. 2024 Dec 4;12(5):101479. doi: 10.1016/j.gendis.2024.101479. eCollection 2025 Sep.
2
Prevalence of fibroblast growth factor receptor 1 (FGFR1) amplification in squamous cell carcinomas of the head and neck.头颈部鳞状细胞癌中成纤维细胞生长因子受体1（FGFR1）扩增的患病率。
J Cancer Res Clin Oncol. 2018 Jan;144(1):53-61. doi: 10.1007/s00432-017-2528-x. Epub 2017 Oct 11.
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Carvacrol suppresses proliferation and invasion in human oral squamous cell carcinoma.香芹酚抑制人口腔鳞状细胞癌的增殖和侵袭。
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Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.反口腔鳞状细胞癌香芹酚通过抑制与 Nrf2/Keap1 通路相关的炎症、增殖和迁移的作用。
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Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer.定义荧光原位杂交评分可识别鳞状细胞肺癌中的高水平和低水平 FGFR1 扩增类型。
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本文引用的文献

1
FGFR-targeted therapeutics: clinical activity, mechanisms of resistance and new directions.成纤维细胞生长因子受体靶向治疗药物：临床活性、耐药机制及新方向。
Nat Rev Clin Oncol. 2024 Apr;21(4):312-329. doi: 10.1038/s41571-024-00869-z. Epub 2024 Feb 29.
2
Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis-Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment.口腔黏膜下纤维性变衍生口腔鳞状细胞癌及其肿瘤微环境的空间转录组学和代谢组学图谱。
Adv Sci (Weinh). 2024 Mar;11(12):e2306515. doi: 10.1002/advs.202306515. Epub 2024 Jan 16.
3
FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis.
FGFR1 SUMOylation 协调血管生成中的内皮血管生成信号。
Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2202631119. doi: 10.1073/pnas.2202631119. Epub 2022 Jun 21.
4
Carvacrol suppresses proliferation and invasion in human oral squamous cell carcinoma.香芹酚抑制人口腔鳞状细胞癌的增殖和侵袭。
Onco Targets Ther. 2016 Apr 18;9:2297-304. doi: 10.2147/OTT.S98875. eCollection 2016.