Verghese Joe, Sreeram Sharika, Joseph Vijin, Adhikari Dristi, Sigamani Alben, Blumen Helena M, Kumar V G Pradeep, Ayers Emmeline
Departments of Neurology, Renaissance School of Medicine, NY, USA.
Institute of Neurosciences, Baby Memorial Hospital, Kozhikode, India.
Gerontology. 2025 Apr;71(4):292-296. doi: 10.1159/000544121. Epub 2025 Feb 13.
Presence of cardiovascular disease is linked to the prevalence and incidence of Motoric Cognitive Risk syndrome (MCR), a pre-dementia syndrome characterized by cognitive complaints and slow gait. Electrocardiograms (ECGs) may offer a cost-effective, non-invasive, and reliable method for detecting cardiovascular abnormalities in individuals with MCR. This approach can not only diagnose cardiovascular disease but also facilitate timely interventions to prevent further cognitive decline in MCR cases.
We examined the association of ECG abnormalities with prevalent MCR in 451 older adults with ECGs participating in the Kerala Einstein Study (KES), based in Indian state of Kerala. Logistic regression analysis adjusted for age and sex were used to examine associations, and reported as odds ratios (OR) with 95% confidence intervals (CI).
ECG abnormalities were present in 191 (42.4%) participants. Of the 43 participants diagnosed with MCR, 23 (53.5%) had ECG abnormalities. Abnormal Q waves (OR 5.1, 95% CI 1.7-14.9) and heart block (OR 6.0, 95% CI 2.1-17.4) were more common in individuals with MCR compared to controls. There were no statistically significant group differences in the prevalence of other ECG abnormalities.
ECG abnormalities are common in MCR patients, and can be considered for cardiovascular disease risk-stratification in MCR cases.
心血管疾病的存在与运动认知风险综合征（MCR）的患病率和发病率相关，MCR是一种以认知主诉和步态缓慢为特征的痴呆前综合征。心电图（ECG）可能为检测MCR个体的心血管异常提供一种经济有效、非侵入性且可靠的方法。这种方法不仅可以诊断心血管疾病，还能促进及时干预，以防止MCR患者的认知功能进一步下降。
我们在印度喀拉拉邦进行的喀拉拉爱因斯坦研究（KES）中，对451名有心电图检查的老年人进行了心电图异常与MCR患病率的关联研究。采用经年龄和性别调整的逻辑回归分析来检验关联，并以比值比（OR）及95%置信区间（CI）报告结果。
191名（42.4%）参与者存在心电图异常。在43名被诊断为MCR的参与者中，23名（53.5%）有心电图异常。与对照组相比，MCR个体中异常Q波（OR 5.1，95%CI 1.7 - 14.9）和心脏传导阻滞（OR 6.0，95%CI 2.1 - 17.4）更为常见。其他心电图异常的患病率在两组之间无统计学显著差异。
心电图异常在MCR患者中很常见，可用于MCR病例的心血管疾病风险分层。
