Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Edinburgh Dementia Prevention Group, University of Edinburgh, Edinburgh, UK.
Int J Geriatr Psychiatry. 2022 Nov;37(11). doi: 10.1002/gps.5824.
Motoric Cognitive Risk (MCR) is a gait-based predementia syndrome that is easy to measure and prognostic of dementia and falls. We aimed to examine the prevalence and risk factors for MCR, and assess its overlap with Mild Cognitive Impairment, Prefrailty, and Frailty, in a cohort of older Scottish adults without dementia.
In this longitudinal prospective study, we classified 690 participants (mean [SD] age 76.3 [0.8] years; wave 3) of the Lothian Birth Cohort 1936 (LBC1936) into non-MCR or MCR groups. We examined their baseline (age 69.5 [0.8] years; wave 1) risk factors for MCR at waves 3, 4, and 5 (6, 9, and 12 years later respectively).
MCR prevalence rate ranged from 5.3% to 5.7% across the three waves. The presence of MCR was associated with older baseline age (6 and 9 years later), lower occupational socioeconomic status (6 years later), and worse scores in a range of tests of executive function (6, 9 and 12 years later). Approximately 46% of the MCR group also had Mild Cognitive Impairment, and almost everyone in the MCR group had either Prefrailty or Frailty.
The prevalence of MCR in this Scottish cohort is lower than the pooled global average, possibly reflecting the general good health of the LBC cohort. However, it is higher than the prevalence in two neighbouring countries' cohorts, which may reflect the younger average ages of those cohorts. Future LBC1936 research should assess the risk factors associated with MCR to validate previous findings and analyse novel predictive factors, particularly socioeconomic status.
运动认知风险（MCR）是一种基于步态的前驱痴呆综合征，易于测量，并且与痴呆和跌倒相关。我们旨在检查无痴呆的老年苏格兰成年人队列中 MCR 的患病率和危险因素，并评估其与轻度认知障碍、衰弱前期和衰弱的重叠情况。
在这项纵向前瞻性研究中，我们将 Lothian 出生队列 1936 年（LBC1936）的 690 名参与者（平均[标准差]年龄 76.3[0.8]岁；第 3 波）分为非 MCR 或 MCR 组。我们在第 3、4 和 5 波（分别为 6、9 和 12 年后）检查了他们的基线（年龄 69.5[0.8]岁；第 1 波）发生 MCR 的危险因素。
MCR 的患病率在三个波次中从 5.3%到 5.7%不等。存在 MCR 与基线年龄较大（6 年后和 9 年后）、职业社会经济地位较低（6 年后）以及一系列执行功能测试的评分较差（6 年后、9 年后和 12 年后）有关。大约 46%的 MCR 组也患有轻度认知障碍，而且 MCR 组中的几乎每个人都存在衰弱前期或衰弱。
在这个苏格兰队列中，MCR 的患病率低于全球平均水平，这可能反映了 LBC 队列的总体健康状况。然而，它高于两个邻国队列的患病率，这可能反映了这些队列的平均年龄较小。未来的 LBC1936 研究应该评估与 MCR 相关的危险因素，以验证先前的发现，并分析新的预测因素，特别是社会经济地位。
