Boulu P, De Broucker T, Maître P, Meunier S, Willer J C
Rev Electroencephalogr Neurophysiol Clin. 1985 Jul;15(1):19-25. doi: 10.1016/s0370-4475(85)80031-9.
The characteristics of the late components of the somatosensory evoked potential (SEP) as a function of stimulation intensity have been studied in 10 normal volunteers following electrical stimulation of the distal cutaneous branches of the median nerve. The stimulus intensity (either single shock or train) was adapted in order to produce the following 4 types of sensation: liminal tactile (ST); frankly tactile but never painful (4 times ST); pain threshold (SD); and 1.5 time SD. A significant relationship was observed between the amplitude of the late component (N150-P220-N400), of the SEP and the stimulus intensity for a low rate of stimulation (below 0.25 Hz). In contrast this relationship is not verified for higher stimulation rates. These data are discussed with respect to their implication in pain research.
在对10名正常志愿者的正中神经远端皮支进行电刺激后，研究了体感诱发电位（SEP）晚期成分的特征与刺激强度之间的关系。调整刺激强度（单次电击或串刺激）以产生以下4种感觉类型：阈下触觉（ST）；明确的触觉但从不疼痛（4倍ST）；疼痛阈值（SD）；以及1.5倍SD。在低刺激频率（低于0.25Hz）下，观察到SEP晚期成分（N150 - P220 - N400）的幅度与刺激强度之间存在显著关系。相比之下，在较高刺激频率下这种关系未得到证实。针对这些数据在疼痛研究中的意义进行了讨论。
