Chauhan Akshay, Ranganath Nischal, Scott John P, Vergidis Paschalis, Roden Anja C, Spencer Philip J, Villavicencio Mauricio A, Daly Richard C, Saddoughi Sahar A
Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
Section of Infectious Disease, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
JHLT Open. 2025 Apr 1;8:100247. doi: 10.1016/j.jhlto.2025.100247. eCollection 2025 May.
Redo-bilateral lung transplant in previous heart-lung transplant is a rare operation. We describe our surgical and medical management experience with a heart-lung transplant recipient who developed chronic lung allograft dysfunction and invasive apiospermum infection. The patient underwent a redo-bilateral lung transplant followed by a combination of inhaled voriconazole, caspofungin, and olorofim for a prolonged period. We observed no issues with bronchial anastomosis healing, and the patient is doing well on 1-year follow-up. This report outlines a successful management approach to this rare complication of heart-lung transplant recipients.
既往心肺移植患者再次进行双侧肺移植是一种罕见的手术。我们描述了一名心肺移植受者出现慢性肺移植功能障碍和侵袭性阿皮芽孢菌感染后的手术及内科治疗经验。该患者接受了再次双侧肺移植,随后长期联合使用吸入伏立康唑、卡泊芬净和奥拉氟进行治疗。我们观察到支气管吻合口愈合无问题,患者在1年随访时情况良好。本报告概述了针对心肺移植受者这种罕见并发症的成功管理方法。