Sagara Saki, Otsuka Kenichiro, Shimada Ryuichi, Iwao Masao, Honda Shuhei, Okuhiro Kazuki, Yoshida Masaki, Daa Tsutomu, Asayama Yoshiki
Department of Radiology, Oita University Faculty of Medicine, 1-1, Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan.
Department of Gastroenterology, Oita University Faculty of Medicine, 1-1, Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan.
Radiol Case Rep. 2025 May 15;20(8):3801-3805. doi: 10.1016/j.radcr.2025.04.102. eCollection 2025 Aug.
Post-transplant lymphoproliferative disorder (PTLD) is a general term describing lymphoproliferative disorders that develop against the background of immunosuppression after organ transplantation, and that range from benign tumors to malignant lymphoma. PTLD is relatively rare after liver transplantation, and there are few cases of post-liver transplant lymphoma with lesions in the clivus. We here describe the case of a patient who visited our hospital complaining of diplopia after a liver transplant. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) revealed lesions with high FDG uptake in the clivus and throughout the body, and the patient was diagnosed with lymphoproliferative disease after liver transplantation. The diplopia was thought to have been caused by the clivus lesion infiltrating into the abducens nerve. In patients after organ transplantation, care must be taken to watch for onset of PTLD, and FDG-PET/CT is thought to be useful for its diagnosis.
移植后淋巴细胞增生性疾病（PTLD）是一个通用术语，用于描述在器官移植后免疫抑制背景下发生的淋巴细胞增生性疾病，其范围从良性肿瘤到恶性淋巴瘤。PTLD在肝移植后相对罕见，很少有肝移植后淋巴瘤累及斜坡的病例。我们在此描述一例肝移植后因复视而就诊我院的患者。氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）显示斜坡及全身有FDG摄取高的病变，该患者被诊断为肝移植后淋巴细胞增生性疾病。复视被认为是由斜坡病变侵犯展神经所致。对于器官移植后的患者，必须注意观察PTLD的发生，FDG-PET/CT被认为对其诊断有用。
