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近期接种疫苗后发生自身免疫性溶血性贫血及疑似急性出血性播散性脑脊髓炎的罕见病例

A Rare Case of Autoimmune Hemolytic Anemia and Suspected Acute Hemorrhagic Disseminated Encephalomyelitis Following Recent Vaccination.

作者信息

Karunaratne Hettiyadura Apsara Surangani Mendis, De Silva Karunakalage Anya A

机构信息

Department of General Medicine, North West Regional Hospital, Burnie, AUS.

出版信息

Cureus. 2025 May 6;17(5):e83556. doi: 10.7759/cureus.83556. eCollection 2025 May.

Abstract

Autoimmune hemolytic anemia (AIHA) and acute disseminated encephalomyelitis (ADEM) are rare autoimmune complications that may follow infections or vaccinations. We present a case of a 77-year-old male patient who developed warm AIHA and rapid neurological decline suggestive of hemorrhagic ADEM following recent varicella and influenza vaccinations. Laboratory findings confirmed AIHA, and MRI revealed multifocal white matter lesions with hemorrhagic foci. Despite high-dose corticosteroid treatment, the patient's condition worsened, and he ultimately passed away.

摘要

自身免疫性溶血性贫血(AIHA)和急性播散性脑脊髓炎(ADEM)是感染或接种疫苗后可能出现的罕见自身免疫性并发症。我们报告一例77岁男性患者,在近期接种水痘和流感疫苗后出现温抗体型自身免疫性溶血性贫血以及提示出血性急性播散性脑脊髓炎的快速神经功能衰退。实验室检查结果确诊为自身免疫性溶血性贫血,磁共振成像(MRI)显示多灶性白质病变伴出血灶。尽管给予了大剂量皮质类固醇治疗,患者病情仍恶化,最终死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4144/12141602/cc7036941bae/cureus-0017-00000083556-i01.jpg

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