Perrodin M, Sérougne C, Lutton C
Reprod Nutr Dev (1980). 1985;25(4A):659-69. doi: 10.1051/rnd:19850507.
In the main organs of the digestive tract of rats fed a semi-purified diet containing 0.5% cholesterol, cholesterol activity was measured 70 min and 8, 24 and 48 h after subcutaneous impulsion of 14C-acetate or intravenous injection of tritiated water. Cholesterol synthesized in the stomach and caecum-colon was not significantly renewed during the 48-hour experiment. On the contrary, cholesterol synthesized in situ in the intestine disappeared with a mean rate constant of 4% X h-1. The rate constant (K) varied (6% X h-1 in the duodenum and jejunum and about 3% X h-1 in the distal ileum) according to the site of the enterocytes in the small intestine. Cell sloughing could not account for the major part of the decrease in cholesterol radioactivity, particularly in the first three quarters of the small intestine. In the proximal half of the gut internal cholesterol secretion via lipoproteins poured into the lymph might play a role.
在喂食含0.5%胆固醇的半纯化饮食的大鼠的消化道主要器官中，在皮下注射14C-乙酸盐70分钟后以及静脉注射氚水8、24和48小时后测量胆固醇活性。在48小时的实验期间，胃和盲肠-结肠中合成的胆固醇没有明显更新。相反，肠道原位合成的胆固醇以平均4%×小时-1的速率常数消失。速率常数（K）根据小肠中肠细胞的位置而变化（十二指肠和空肠中为6%×小时-1，回肠末端约为3%×小时-1）。细胞脱落不能解释胆固醇放射性降低的主要部分，特别是在小肠的前三分之二部分。在肠道近端的一半，通过倒入淋巴中的脂蛋白进行的内部胆固醇分泌可能起作用。
