大鼠胃肠道不同区域的去甲肾上腺素浓度及周转率：一种评估肠道交感神经活动的方法。
Noradrenaline concentration and turnover in different regions of the gastrointestinal tract of the rat: an approach to the evaluation of sympathetic activity in the gut.
作者信息
Taubin H L, Djahanguiri B, Landsberg L
出版信息
Gut. 1972 Oct;13(10):790-5. doi: 10.1136/gut.13.10.790.
Abstract
The endogenous noradrenaline concentration, fractional turnover, half-life, and turnover rate of tritiated ((3)H) noradrenaline were determined in the oesophagus, non-glandular and glandular portions of the stomach, duodenum, jejunum, ileum, and colon of the rat. The highest concentration of endogenous noradrenaline was present in the duodenum and colon. The (3)H-noradrenaline fractional turnover rates and half-lives were significantly greater in the small and large intestines as compared with the oesophagus and stomach. The noradrenaline turnover rate, which is an estimate of the level of sympathetic activity, was greatest in the colon and duodenum. This method of assessing sympathetic activity in various tissues by direct measurement of the noradrenaline turnover rate may be applied to the study of the adrenergic nervous system in the physiology and pathophysiology of the gastrointestinal tract.
摘要
测定了大鼠食管、胃的非腺性和腺性部分、十二指肠、空肠、回肠及结肠中内源性去甲肾上腺素的浓度、分数周转率、半衰期以及氚标记（³H）去甲肾上腺素的周转率。内源性去甲肾上腺素浓度最高的部位是十二指肠和结肠。与食管和胃相比，³H-去甲肾上腺素在小肠和大肠中的分数周转率及半衰期显著更高。作为交感神经活动水平估计值的去甲肾上腺素周转率在结肠和十二指肠中最高。通过直接测量去甲肾上腺素周转率来评估不同组织中交感神经活动的这种方法，可应用于研究胃肠道生理和病理生理学中的肾上腺素能神经系统。
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