Yan Jingshuang, Ren Rongrong, Chang Ruqi, Dan Wanyue, Zhang Xiaohan, Pan Fei, Yan Bin, Lee Hongzhe, Josie Ni, Sun Gang, Peng Lihua, Wu Gary D, Yang Yunsheng
Department of Gastroenterology and Hepatology The First Medical Center, Chinese PLA General Hospital Beijing China.
School of Medicine Nankai University Tianjin China.
Chronic Dis Transl Med. 2025 Feb 14;11(2):130-139. doi: 10.1002/cdt3.70000. eCollection 2025 Jun.
The increasing incidence of inflammatory bowel disease (IBD) presents significant medical and societal challenges. A well-designed IBD database is crucial for both epidemiological studies and clinical management. However, inconsistencies between regional databases hinder cross-institutional and international research, especially between Eastern and Western societies.
We developed a new IBD database, the 301 IBD database, integrating the IBD clinical characteristics from the Penn IBD database (USA) and the latest IBD guidelines and consensus and clinical practices of the Chinese PLA General Hospital (PLAGH). We applied this database to analyze clinical data of IBD inpatients at PLAGH from 2008 to 2023.
The 301 IBD database contains 490 items in 6 sections including demographic characteristics, personal history, clinical phenotype, disease activity, laboratory tests and examinations, and treatment. Features of the 301 IBD database include inpatient focus, biochemical indicators and opportunistic infection focus, and more about ulcerative colitis (UC)-associated complications. Single-center analysis revealed an increasing hospitalization trend, from 2.35% in 2008 to 3.94% in 2023. We found that the clinical characteristics of our UC inpatients are predominantly male (62.5%), extensive lesions (55.1%), low usage of biologics (4.1%), and a high incidence of UC-CRC (3.0%). The clinical characteristics of CD inpatients included male predominance (68.39%), early onset age (35.43 ± 14.75-year-old), and high rate of surgery (25.81%).
The 301 IBD database, integrating Eastern and Western clinical data, provides a valuable tool for IBD clinical research. Future international, multicenter collaborations are expected to further enhance its utility.
炎症性肠病（IBD）发病率的不断上升带来了重大的医学和社会挑战。一个设计良好的IBD数据库对于流行病学研究和临床管理都至关重要。然而，区域数据库之间的不一致阻碍了跨机构和国际研究，尤其是东西方社会之间的研究。
我们开发了一个新的IBD数据库，即301 IBD数据库，整合了宾夕法尼亚IBD数据库（美国）的IBD临床特征以及中国人民解放军总医院（PLAGH）的最新IBD指南、共识和临床实践。我们应用该数据库分析了2008年至2023年PLAGH的IBD住院患者的临床数据。
301 IBD数据库包含6个部分的490项内容，包括人口统计学特征、个人史、临床表型、疾病活动、实验室检查和治疗。301 IBD数据库的特点包括以住院患者为重点、生化指标和机会性感染重点以及更多关于溃疡性结肠炎（UC）相关并发症的内容。单中心分析显示住院率呈上升趋势，从2008年的2.35%上升至2023年的3.94%。我们发现，我们的UC住院患者的临床特征主要为男性（62.5%）、广泛病变（55.1%）、生物制剂使用率低（4.1%）以及UC-CRC发病率高（3.0%）。CD住院患者的临床特征包括男性占主导（68.39%）、发病年龄早（35.43±14.75岁）和手术率高（25.81%）。
整合东西方临床数据的301 IBD数据库为IBD临床研究提供了一个有价值的工具。未来的国际多中心合作有望进一步提高其效用。
