Research Center of Clinical Epidemiology, Peking University Third Hospital, Haidian District, Beijing, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Haidian District, Beijing, China.
Healthcare Security Administration of Guangdong Province, Yuexiu District, Guangzhou, Guangdong, China.
Clin Gastroenterol Hepatol. 2023 Dec;21(13):3379-3386.e29. doi: 10.1016/j.cgh.2023.08.013. Epub 2023 Sep 1.
BACKGROUND & AIMS: Limited studies have evaluated the burden of inflammatory bowel disease (IBD) in China. We aimed to estimate the incidence of IBD including ulcerative colitis (UC) and Crohn's disease (CD) in urban China.
The national urban incidence in 2016 was calculated based on urban basic medical insurance from 2012 to 2016 in China by using a 4-year washout period. The incidence in Yinzhou District estimated from the Yinzhou electronic health care record database was used to test the accuracy of the results from insurance data.
A total of 95,555 patients with IBD were identified. The incidence in 2016 was 10.04 (95% confidence interval, 6.95-13.71) per 100,000 person-years. The incidence rates of both UC and CD were higher among males than among females. There was a sharp increase in UC incidence before the age of 30 years and stabilization in later years (50-79 years old), whereas CD incidence peaked at 30 to 34 years old and experienced decline subsequently. The incidence of UC was much greater than that of CD, with a UC-to-CD incidence ratio of 12.61. The results from the Yinzhou database confirmed these results.
This study is the first to draw a portrait of the distribution of IBD in urban China. The difference in IBD incidence between urban China and other countries suggests an association between the IBD burden and industrialization process. The accelerating urbanization and industrialization process in China, a country with a population of 1.4 billion people, will likely increase the burden of IBD.
有限的研究评估了中国炎症性肠病（IBD）的负担。我们旨在估计包括溃疡性结肠炎（UC）和克罗恩病（CD）在内的中国城市 IBD 的发病率。
2016 年全国城市发病率是根据中国 2012 年至 2016 年城市基本医疗保险，使用 4 年洗脱期计算得出的。使用鄞州区电子健康记录数据库中的鄞州区发病率来测试保险数据结果的准确性。
共发现 95555 例 IBD 患者。2016 年的发病率为 10.04（95%置信区间，6.95-13.71）/100000 人年。UC 和 CD 的发病率在男性中均高于女性。UC 的发病率在 30 岁之前急剧上升，之后趋于稳定（50-79 岁），而 CD 的发病率在 30-34 岁达到峰值，随后下降。UC 的发病率远高于 CD，UC 与 CD 的发病率比为 12.61。鄞州区数据库的结果证实了这些结果。
本研究首次描绘了中国城市 IBD 的分布特征。中国与其他国家之间 IBD 发病率的差异表明 IBD 负担与工业化进程之间存在关联。中国这个拥有 14 亿人口的国家，城市化和工业化进程的加速可能会增加 IBD 的负担。
