Kjeldsen Caitlin P, Neel Mary Lauren, Stark Ann R, He Zhulin, Chorna Olena, Benninger Kristen, Maitre Nathalie L
Emory University School of Medicine, Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Mind Brain Educ. 2025 Feb;10(1):37-46. doi: 10.1111/mbe.70000. Epub 2025 Feb 22.
Neurologic insults in infancy can have significant long-term effects on developmental processes including attention and learning; however, heterogeneity of diagnoses and treatments in this population often lead to exclusion from interventional trials to improve outcome. This study sought to determine whether hospitalized infants with neural insults have the capacity to attend to and engage in an intervention leveraging recorded mother's voice contingent on non-nutritive suck (NNS). Eighty-four hospitalized infants with neural insult were randomized to receive 20 sessions of intervention (recorded mother's voice contingent on NNS) or control (passive exposure to recorded mother's voice). Pause time between suck bursts was 29% lower for infants receiving contingent mother's voice compared to passive exposure (<.001). Hospitalized infants with evidence of neural insult have the capacity to engage in active interventions leveraging recorded mother's voice and demonstrate greater attention during active versus passive presentation of stimuli. Clinical Trial Registration: NCT03230032.
婴儿期的神经损伤会对包括注意力和学习在内的发育过程产生重大的长期影响；然而，该人群诊断和治疗的异质性往往导致被排除在改善预后的干预试验之外。本研究旨在确定患有神经损伤的住院婴儿是否有能力参与并接受一种基于非营养性吸吮（NNS）的、利用母亲录音声音的干预措施。84名患有神经损伤的住院婴儿被随机分为两组，一组接受20次干预（基于NNS的母亲录音声音），另一组为对照组（被动接触母亲录音声音）。与被动接触相比，接受有条件母亲声音的婴儿吸吮间歇时间缩短了29%（<.001）。有神经损伤证据的住院婴儿有能力参与基于母亲录音声音的积极干预，并在刺激的主动呈现与被动呈现过程中表现出更高的注意力。临床试验注册号：NCT03230032。
