D Chorna Olena, L Hamm Ellyn, Shrivastava Hemang, Maitre Nathalie L
a Center for Perinatal Research and Department of Pediatrics at Nationwide Children's Hospital , Columbus , OH , USA.
b Department of Hearing and Speech Sciences , Vanderbilt University Medical Center , Nashville , TN , USA.
Dev Neuropsychol. 2018;43(2):123-134. doi: 10.1080/87565641.2018.1433671.
Atypical maturation of auditory neural processing contributes to preterm-born infants' language delays. Event-related potential (ERP) measurement of speech-sound differentiation might fill a gap in treatment-response biomarkers to auditory interventions. We evaluated whether these markers could measure treatment effects in a quasi-randomized prospective study. Hospitalized preterm infants in passive or active, suck-contingent mother's voice exposure groups were not different at baseline. Post-intervention, the active group had greater increases in/du/-/gu/differentiation in left frontal and temporal regions. Infants with brain injury had lower baseline/ba/-/ga/and/du/-/gu/differentiation than those without. ERP provides valid discriminative, responsive, and predictive biomarkers of infant speech-sound differentiation.
听觉神经处理的非典型成熟导致早产儿语言发育迟缓。对语音辨别进行事件相关电位（ERP）测量可能会填补听觉干预治疗反应生物标志物方面的空白。我们在一项准随机前瞻性研究中评估了这些标志物是否能够测量治疗效果。被动或主动接受以吮吸为条件的母亲声音暴露组的住院早产儿在基线时并无差异。干预后，主动组在左额叶和颞叶区域的/du/-/gu/辨别能力有更大提高。有脑损伤的婴儿的基线/ba/-/ga/和/du/-/gu/辨别能力低于无脑损伤的婴儿。ERP为婴儿语音辨别提供了有效的鉴别、反应性和预测性生物标志物。
