Wang Chunmei, Zeng Jianting, Liu Hongduan, Zhang Li
Department of Medical Oncology, Chongqing University Cancer Hospital, 181 Hanyu Road, Shapingba District, Chongqing 400030, China.
Department of Hepatobiliary Pancreatic Tumor Center, Chongqing University Cancer Hospital, 181 Hanyu Road, Shapingba District, Chongqing 400030, China.
Am J Prev Cardiol. 2025 May 12;22:101005. doi: 10.1016/j.ajpc.2025.101005. eCollection 2025 Jun.
Lifestyle behaviors may be an important means of preventing hypertension. The causal relationship between physical activity, sleep duration, sedentary behavior, and hypertension remains unclear. The aim of this study was to examine these associations by using Mendelian randomization (MR) analysis.
Single nucleotide polymorphisms associated with sedentary behavior patterns (including length of mobile phone use, time spent driving, time spent watching television, and time spent playing computer games), duration of walks, sleep duration, and moderate-to-vigorous intensity physical activity (MVPA) at genome-wide significance ( < 5 × 10) were selected as instrumental variables (IVs) from a genome-wide association study. These IVs represented exposure factors in the subsequent analysis. Summary statistics for hypertension were obtained from the FinnGen Biobank study. In MR analysis, inverse-variance weighting (IVW), weighted median, and MR-Egger regression were employed for causal inference. In addition, multivariate MR analysis was applied to explore the potential confounding effects of smoking and education on the causal relationships between exposure factors and hypertension. A mediation analysis was conducted to assess whether body mass index (BMI) and waist-hip ratio (WHR) mediated the associations between exposure factors and hypertension.
The IVW analysis indicated that increased time spent watching television was associated with an increased risk of hypertension (OR: 1.831; 95 %CI: 1.482-2.262; = 1.99E-08). The multivariate MR analysis demonstrated that the effect of television viewing time on hypertension remained significant after adjusting for smoking. However, after adjusting for education level, no significant association was observed between television viewing time and hypertension. Mediation analysis revealed that BMI and WHR mediated the causal relationship between television viewing time and hypertension. Genetically predicted other sedentary behavior factors, duration of walks, sleep duration, and MVPA were not significantly associated with hypertension.
In conclusion, this MR study revealed that a lifestyle of increased time spent watching television may contribute to an elevated risk of hypertension.
生活方式行为可能是预防高血压的重要手段。身体活动、睡眠时间、久坐行为与高血压之间的因果关系仍不明确。本研究的目的是通过孟德尔随机化（MR）分析来检验这些关联。
从全基因组关联研究中选择与久坐行为模式（包括手机使用时长、驾车时间、看电视时间和玩电脑游戏时间）、步行时长、睡眠时间以及中等至剧烈强度身体活动（MVPA）在全基因组水平显著相关（<5×10）的单核苷酸多态性作为工具变量（IVs）。这些IVs在后续分析中代表暴露因素。高血压的汇总统计数据来自芬兰生物银行研究。在MR分析中，采用逆方差加权（IVW）、加权中位数和MR-Egger回归进行因果推断。此外，应用多变量MR分析来探讨吸烟和教育对暴露因素与高血压之间因果关系的潜在混杂效应。进行中介分析以评估体重指数（BMI）和腰臀比（WHR）是否介导了暴露因素与高血压之间的关联。
IVW分析表明，看电视时间增加与高血压风险增加相关（OR：1.831；95%CI：1.482 - 2.262；P = 1.99E - 08）。多变量MR分析表明，调整吸烟因素后，看电视时间对高血压的影响仍然显著。然而，调整教育水平后，未观察到看电视时间与高血压之间存在显著关联。中介分析显示，BMI和WHR介导了看电视时间与高血压之间的因果关系。基因预测的其他久坐行为因素、步行时长、睡眠时间和MVPA与高血压无显著关联。
总之，这项MR研究表明，看电视时间增加的生活方式可能会增加高血压风险。
