lncRNA ATB和SNHG16表达水平在肝细胞癌患者中的预后意义
Prognostic Significance of lncRNA ATB and SNHG16 Expression Levels in Patients with Hepatocellular Carcinoma.
作者信息
Ravanshad Sahar, Taherynejad Mohammadhossein, Gerami Zohre, Dalili Amin, Ayatollahi Hossein, Mehrad-Majd Hassan
机构信息
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Iran J Pathol. 2025 Spring;20(2):152-158. doi: 10.30699/ijp.2025.2044199.3368. Epub 2025 Oct 30.
BACKGROUND & OBJECTIVE: Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, a major component of noncoding RNAs. Previous studies have shown the oncogenic role of various lncRNAs. This study aimed to explore the expression and prognostic value of ATB and SNHG16 in patients with hepatocellular carcinoma.
METHODS
ATB and SNHG16 expression in tumor and adjacent normal tissues was identified using real-time quantitative PCR. In this study, patients were divided into 2 groups based on the expression level of each gene, and the correlation between expression level and clinicopathological features of patients with HCC was investigated. All data were analyzed using SPSS version 22.
RESULTS
Of the lncRNAs examined in this study, ATB was expressed at significantly higher levels in tumor tissues. However, this overexpression was not associated with any clinicopathological features of HCC patients.
CONCLUSION
In this study, overexpression of ATB and SNHG16 was not associated with survival rate or clinicopathological features of patients with hepatocellular carcinoma.
背景与目的
长链非编码RNA（lncRNAs）是长度超过200个核苷酸的转录本，是非编码RNA的主要组成部分。以往研究显示多种lncRNAs具有致癌作用。本研究旨在探讨ATB和SNHG16在肝细胞癌患者中的表达及预后价值。
方法
采用实时定量PCR检测肿瘤组织及癌旁正常组织中ATB和SNHG16的表达。本研究根据每个基因的表达水平将患者分为两组，并研究表达水平与肝癌患者临床病理特征之间的相关性。所有数据均使用SPSS 22版进行分析。
结果
在本研究检测的lncRNAs中，ATB在肿瘤组织中的表达水平显著更高。然而，这种过表达与肝癌患者的任何临床病理特征均无关联。
结论
在本研究中，ATB和SNHG16的过表达与肝细胞癌患者的生存率或临床病理特征无关。
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