Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Malaysia.
Pharm Biol. 2021 Dec;59(1):494-503. doi: 10.1080/13880209.2021.1910716.
Pectin is a plant heteropolysaccharide that is biocompatible and biodegradable, enabling it to be an excellent reducing agent (green synthesis) for metallic nanoparticles (MNPs). Nevertheless, in the biological industry, pectin has been left behind in synthesising MNPs, for no known reason.
To systematically review the biological activities of pectin synthesised MNPs (Pe-MNPs).
The databases Springer Link, Scopus, ScienceDirect, Google Scholar, PubMed, Mendeley, and ResearchGate were systematically searched from the date of their inception until 10 February 2020. Pectin, green synthesis, metallic nanoparticles, reducing agent and biological activities were among the key terms searched. The data extraction was focussed on the biological activities of Pe-MNPs and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for systematic reviews.
A total of 15 studies outlined 7 biological activities of Pe-MNPs in the only three metals that have been explored, namely silver (Ag), gold (Au) and cerium oxide (CeO). The activities reported from the and studies were antimicrobial (9 studies), anticancer (2 studies), drug carrier (3 studies), non-toxic (4 studies), antioxidant (2 studies), wound healing (1 study) and anti-inflammation (1 study).
This systematic review demonstrates the current state of the art of Pe-MNPs biological activities, suggesting that Ag and Au have potent antibacterial and anticancer/chemotherapeutic drug carrier activity, respectively. Further , and clinical research is crucial for a better understanding of the pharmacological potential of pectin synthesised MNPs.
果胶是一种植物杂多糖，具有生物相容性和可生物降解性，使其成为金属纳米粒子（MNPs）的优秀还原剂（绿色合成）。然而，在生物工业中，果胶在合成 MNPs 方面一直落后，原因不明。
系统综述果胶合成 MNPs（Pe-MNPs）的生物学活性。
系统检索 Springer Link、Scopus、ScienceDirect、Google Scholar、PubMed、Mendeley 和 ResearchGate 数据库，检索时间从建库开始至 2020 年 2 月 10 日。果胶、绿色合成、金属纳米粒子、还原剂和生物学活性是检索的关键词。数据提取重点是 Pe-MNPs 的生物学活性，并按照系统评价的 Preferred Reporting Items for Systematic Reviews and Meta-Analyses（PRISMA）建议进行报告。
共有 15 项研究概述了仅在三种已探索金属（银（Ag）、金（Au）和氧化铈（CeO））中 Pe-MNPs 的 7 种生物学活性。和研究报道的活性包括抗菌（9 项研究）、抗癌（2 项研究）、药物载体（3 项研究）、无毒（4 项研究）、抗氧化（2 项研究）、伤口愈合（1 项研究）和抗炎（1 项研究）。
本系统评价展示了 Pe-MNPs 生物学活性的最新进展，表明 Ag 和 Au 分别具有较强的抗菌和抗癌/化疗药物载体活性。进一步的毒理学、临床试验和临床研究对于更好地理解果胶合成 MNPs 的药理学潜力至关重要。
