Shao Meng-Qiu, Liao Jia-Bao, Zhai Man-Yin, Wan Qian-Qian, Jiang Li-Juan, Cui Huan-Tian
First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650000, Yunnan Province, China.
Department of Critical Care Medicine, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing 314000, Zhejiang Province, China.
World J Diabetes. 2025 May 15;16(5):103447. doi: 10.4239/wjd.v16.i5.103447.
In this article, we comment on an article by Wang published in the . Existing treatments with oral medications can partially mitigate the toxicity of elevated blood glucose levels in patients with type 2 diabetes mellitus. However, these patients often require lifelong, costly medications, and many struggle with poor compliance. To address the limitations of pharmacological treatments, laparoscopic jejunal-ileal lateral anastomosis has become increasingly common in clinical practice and generally yields favorable outcomes. This procedure stimulates the secretion of larger amounts of glucagon-like peptide-1 by intestinal L cells, which in turn promotes pancreatic islet cell proliferation, reduces insulin resistance, and effectively controls glucose and lipid metabolism disorders. Nonetheless, further research is needed to fully explore its indications, contraindications, the enhancement of patients' quality of life and patients' satisfaction with the subjective experience of treatment and long-term effects.
在本文中，我们对王发表在《 》上的一篇文章进行评论。现有的口服药物治疗可以部分减轻2型糖尿病患者血糖水平升高的毒性。然而，这些患者通常需要终身服用昂贵的药物，而且许多患者在依从性方面存在困难。为了解决药物治疗的局限性，腹腔镜空肠-回肠侧侧吻合术在临床实践中越来越普遍，并且总体上产生了良好的效果。该手术刺激肠道L细胞分泌大量胰高血糖素样肽-1，进而促进胰岛细胞增殖，降低胰岛素抵抗，并有效控制糖脂代谢紊乱。尽管如此，仍需要进一步研究以充分探索其适应症、禁忌症、对患者生活质量的改善以及患者对治疗主观体验和长期效果的满意度。
