Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation.
作者信息
Zhai Yizhan, Cai Jianfeng
机构信息
Department of Chemistry, University of South Florida, Tampa, FL 33620, United States.
出版信息
Acta Pharm Sin B. 2025 May;15(5):2808-2809. doi: 10.1016/j.apsb.2025.04.023. Epub 2025 May 14.
Abstract
摘要
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本文引用的文献
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Targeted protein degradation: advances in drug discovery and clinical practice.靶向蛋白降解：药物发现和临床实践的进展。
Signal Transduct Target Ther. 2024 Nov 6;9(1):308. doi: 10.1038/s41392-024-02004-x.
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Targeted protein degradation: from mechanisms to clinic.靶向蛋白降解：从机制到临床。
Nat Rev Mol Cell Biol. 2024 Sep;25(9):740-757. doi: 10.1038/s41580-024-00729-9. Epub 2024 Apr 29.
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Targeting the undruggables-the power of protein degraders.靶向不可成药靶点——蛋白降解剂的威力。
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Recent Discovery and Development of Inhibitors that Target CDK9 and Their Therapeutic Indications.近期靶向 CDK9 的抑制剂的发现与研发及其治疗用途。
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Hydrophobic tag-based protein degradation: Development, opportunity and challenge.基于疏水标签的蛋白质降解：发展、机遇与挑战。
Eur J Med Chem. 2023 Nov 15;260:115741. doi: 10.1016/j.ejmech.2023.115741. Epub 2023 Aug 19.
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Targeted protein degradation: mechanisms, strategies and application.靶向蛋白降解：机制、策略与应用。
Signal Transduct Target Ther. 2022 Apr 4;7(1):113. doi: 10.1038/s41392-022-00966-4.
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Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update.CDK9 抑制剂的生物学和药物化学研究进展：最新综述。
J Med Chem. 2020 Nov 25;63(22):13228-13257. doi: 10.1021/acs.jmedchem.0c00744. Epub 2020 Sep 17.
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Lysosome biology in autophagy.自噬中的溶酶体生物学
Cell Discov. 2020 Feb 11;6:6. doi: 10.1038/s41421-020-0141-7. eCollection 2020.
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