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Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation.

作者信息

Zhai Yizhan, Cai Jianfeng

机构信息

Department of Chemistry, University of South Florida, Tampa, FL 33620, United States.

出版信息

Acta Pharm Sin B. 2025 May;15(5):2808-2809. doi: 10.1016/j.apsb.2025.04.023. Epub 2025 May 14.

Abstract
摘要

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本文引用的文献

1
Targeted protein degradation: advances in drug discovery and clinical practice.
Signal Transduct Target Ther. 2024 Nov 6;9(1):308. doi: 10.1038/s41392-024-02004-x.
2
Targeted protein degradation: from mechanisms to clinic.
Nat Rev Mol Cell Biol. 2024 Sep;25(9):740-757. doi: 10.1038/s41580-024-00729-9. Epub 2024 Apr 29.
3
Targeting the undruggables-the power of protein degraders.
Sci Bull (Beijing). 2024 Jun 15;69(11):1776-1797. doi: 10.1016/j.scib.2024.03.056. Epub 2024 Mar 29.
4
Recent Discovery and Development of Inhibitors that Target CDK9 and Their Therapeutic Indications.
J Med Chem. 2024 Apr 11;67(7):5185-5215. doi: 10.1021/acs.jmedchem.4c00312. Epub 2024 Apr 2.
5
Hydrophobic tag-based protein degradation: Development, opportunity and challenge.
Eur J Med Chem. 2023 Nov 15;260:115741. doi: 10.1016/j.ejmech.2023.115741. Epub 2023 Aug 19.
6
Targeted protein degradation: mechanisms, strategies and application.
Signal Transduct Target Ther. 2022 Apr 4;7(1):113. doi: 10.1038/s41392-022-00966-4.
7
Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update.
J Med Chem. 2020 Nov 25;63(22):13228-13257. doi: 10.1021/acs.jmedchem.0c00744. Epub 2020 Sep 17.
8
Lysosome biology in autophagy.
Cell Discov. 2020 Feb 11;6:6. doi: 10.1038/s41421-020-0141-7. eCollection 2020.

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