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Targeting stiff stroma by neutralizing LOX-mediated matrix crosslinking in pancreatic cancer.

作者信息

Zhang Shan, Cai Zhiwei, Jiang Luju, Cai Shuqi, Weng Zheqi, Jiang Shuheng

机构信息

State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Department of General Surgery, Pancreatobiliary Surgery Center, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.

出版信息

Acta Pharm Sin B. 2025 May;15(5):2783-2786. doi: 10.1016/j.apsb.2025.03.010. Epub 2025 Mar 7.

DOI:10.1016/j.apsb.2025.03.010
PMID:40487664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12145025/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd46/12145025/252c57bb971f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd46/12145025/252c57bb971f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd46/12145025/252c57bb971f/gr1.jpg

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本文引用的文献

1
Nanomedicine regulating PSC-mediated intercellular crosstalk: Mechanisms and therapeutic strategies.纳米医学调控PSC介导的细胞间串扰：机制与治疗策略
Acta Pharm Sin B. 2024 Nov;14(11):4756-4775. doi: 10.1016/j.apsb.2024.07.007. Epub 2024 Jul 10.
2
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer.一种首创的泛赖氨酸氧化酶抑制剂可破坏基质重构，增强胰腺癌对吉西他滨的反应和生存。
Nat Cancer. 2023 Sep;4(9):1326-1344. doi: 10.1038/s43018-023-00614-y. Epub 2023 Aug 28.
3
Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.
巨噬细胞通过 LOXL2 介导的级联反应来指导胰腺导管腺癌中的癌细胞转移。
Gut. 2023 Feb;72(2):345-359. doi: 10.1136/gutjnl-2021-325564. Epub 2022 Apr 15.
4
Type I collagen deletion in αSMA myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer.Ⅰ型胶原在 αSMA 肌成纤维细胞中的缺失增强了免疫抑制作用，并加速了胰腺癌的进展。
Cancer Cell. 2021 Apr 12;39(4):548-565.e6. doi: 10.1016/j.ccell.2021.02.007. Epub 2021 Mar 4.
5
The matrix in cancer.癌症中的基质。
Nat Rev Cancer. 2021 Apr;21(4):217-238. doi: 10.1038/s41568-020-00329-7. Epub 2021 Feb 15.
6
Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.胰腺导管腺癌的进展受到基质的抑制。
J Clin Invest. 2020 Sep 1;130(9):4704-4709. doi: 10.1172/JCI136760.
7
Targeting the lysyl oxidases in tumour desmoplasia.靶向肿瘤细胞外基质中的赖氨酰氧化酶。
Biochem Soc Trans. 2019 Dec 20;47(6):1661-1678. doi: 10.1042/BST20190098.
8
Lysyl oxidases: from enzyme activity to extracellular matrix cross-links.赖氨酰氧化酶：从酶活性到细胞外基质交联。
Essays Biochem. 2019 Sep 13;63(3):349-364. doi: 10.1042/EBC20180050.
9
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.靶向赖氨酰氧化酶/缺氧轴可逆转许多使胰腺癌致命的特征：抑制赖氨酰氧化酶可消除转移并增强药物疗效。
EMBO Mol Med. 2015 Aug;7(8):1063-76. doi: 10.15252/emmm.201404827.
10
Matrix crosslinking forces tumor progression by enhancing integrin signaling.基质交联通过增强整合素信号传导促进肿瘤进展。
Cell. 2009 Nov 25;139(5):891-906. doi: 10.1016/j.cell.2009.10.027.