Saito Makoto, Oda Yoshitaka, Sugino Hirokazu, Suzuki Toma, Yokoyama Emi, Kanaya Minoru, Izumiyama Koh, Mori Akio, Morioka Masanobu, Kondo Takeshi
Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
World J Gastrointest Oncol. 2025 May 15;17(5):105448. doi: 10.4251/wjgo.v17.i5.105448.
In addition to nodal lesions, over 30% of mantle cell lymphomas (MCLs) also have gastrointestinal involvement, characteristically presenting as multiple lymphomatous polyposis (MLP), which rarely involve the esophagus. Most related papers have been case reports, and no comprehensive studies have been conducted; thus, the actual clinical situation has remained unknown for a long time.
To elucidate the actual clinical situation of esophageal involvement of MCL presenting with MLP, including its prognosis.
From January 2001 to December 2021, among MCL patients whose gastrointestinal lesions were histopathologically confirmed by endoscopic biopsy at our center, 6 patients with MLP in the esophagus were selected. We retrospectively examined the clinical features of these patients, including their prognosis.
In all patients, multiple lesions were present in the gastrointestinal tract other than the esophagus and in the lymph nodes throughout the body, and most patients also had lesions involving the bone marrow or spleen. Most of the treatments include chemotherapy, with a 50% survival period of less than 2 years and a 5-year survival rate of approximately 30%, indicating a poor prognosis.
Patients with esophageal involvement of the MCL who presented with MLP had a large tumor burden and poor survival.
除淋巴结病变外，超过30%的套细胞淋巴瘤（MCL）还存在胃肠道受累，典型表现为多发性淋巴瘤性息肉病（MLP），很少累及食管。大多数相关论文为病例报告，尚未进行全面研究；因此，实际临床情况长期不明。
阐明表现为MLP的MCL食管受累的实际临床情况，包括其预后。
2001年1月至2021年12月，在本中心经内镜活检组织病理学确诊为胃肠道病变的MCL患者中，选取6例食管有MLP的患者。我们回顾性研究了这些患者的临床特征，包括其预后。
所有患者除食管外的胃肠道及全身淋巴结均有多处病变，大多数患者还伴有骨髓或脾脏病变。大多数治疗包括化疗，中位生存期不到2年，5年生存率约为30%，提示预后较差。
表现为MLP的MCL食管受累患者肿瘤负荷大，生存率低。
