Wen Jimmy, Karabala Muhammad, Muttalib Zohaer, Syed Burhaan, Khalil Ramy, Razick Daniel, Razick Adam, Pai David
California Northstate University College of Medicine Elk Grove California USA.
University of California Los Angeles Los Angeles California USA.
Food Sci Nutr. 2025 Jun 5;13(6):e70407. doi: 10.1002/fsn3.70407. eCollection 2025 Jun.
Watercress (WC) has been used extensively in traditional medicine for various healthcare conditions such as hypertension, hyperglycemia, arthritis, and more. This systematic review evaluates WC's antioxidant and anti-inflammatory markers in human studies. A systematic review search was conducted in PubMed, Embase, and Cochrane Library for studies reporting anti-inflammatory and anti-oxidative markers following WC supplementation, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Study variables included the number of patients, dosage/formulation of WC, mean age, and follow-up time, pre- and post-intervention antioxidant/anti-inflammatory outcomes, and complications. Seven RCTs, including 302 patients with a mean age of 47 years (23-61) and a mean follow-up time of 39 days (21-60), were included in this study. The dosage varied from 85 g/day to 750 mg/kg/day. Antioxidant parameters reported included superoxide dismutase (five studies), ferric-reducing antioxidant power (two studies), glutathione peroxidase (two studies), retinol (two studies), β-carotene (two studies), and α-tocopherol (two studies). Oxidative stress parameters included protein carbonyls (four studies), thiobarbituric acid reactive substances (two studies), malondialdehyde (two studies), nitric oxide (two studies), T-SH (two studies), and CAT (three studies). Inflammatory markers included two studies reporting on tumor necrosis factor-a (two studies) and one study reporting on interleukin-1, interleukin-6, and C-reactive protein. WC administration demonstrated improvement for most antioxidant and anti-inflammatory markers and had a strong safety profile. WC had a positive effect on anti-oxidant and anti-inflammatory markers. However, the relatively short follow-up times and heterogeneous patient demographics and formulations/dosages of WC warrant further studies to assess the benefits of WC.
西洋菜（WC）在传统医学中已被广泛用于治疗各种健康问题，如高血压、高血糖、关节炎等。本系统评价评估了人体研究中WC的抗氧化和抗炎指标。按照系统评价和Meta分析的首选报告项目（PRISMA）指南，在PubMed、Embase和Cochrane图书馆中进行了系统评价检索，以查找报告补充WC后抗炎和抗氧化指标的研究。研究变量包括患者数量、WC的剂量/配方、平均年龄、随访时间、干预前后的抗氧化/抗炎结果以及并发症。本研究纳入了7项随机对照试验，包括302名患者，平均年龄为47岁（23 - 61岁），平均随访时间为39天（21 - 60天）。剂量从85克/天到750毫克/千克/天不等。报告的抗氧化参数包括超氧化物歧化酶（5项研究）、铁还原抗氧化能力（2项研究）、谷胱甘肽过氧化物酶（2项研究）、视黄醇（2项研究）、β-胡萝卜素（2项研究）和α-生育酚（2项研究）。氧化应激参数包括蛋白质羰基（4项研究）、硫代巴比妥酸反应性物质（2项研究）、丙二醛（2项研究）、一氧化氮（2项研究）、总甲状腺素（2项研究）和过氧化氢酶（3项研究）。炎症指标包括2项报告肿瘤坏死因子-α的研究以及1项报告白细胞介素-1、白细胞介素-6和C反应蛋白的研究。服用WC对大多数抗氧化和抗炎指标有改善作用，且安全性良好。WC对抗氧化和抗炎指标有积极影响。然而，随访时间相对较短以及患者人口统计学特征以及WC的配方/剂量存在异质性，因此有必要进一步研究以评估WC的益处。
