Yang Lin, Wang Jinsen, Pan Xiaoyu, Zhang Xueqing, Ban Jiangli, Yue Lin, Ren Lin, Jiang Xiaolan, Chen Shuchun
Department of Internal Medicine Hebei North University Zhangjiakou Hebei People's Republic of China.
Life Sciences Research Center Hebei North University Zhangjiakou Hebei People's Republic of China.
Food Sci Nutr. 2025 Jun 6;13(6):e70340. doi: 10.1002/fsn3.70340. eCollection 2025 Jun.
In a healthy population, abnormal electrocardiographic activity is linked to an increased risk of cardiovascular events. The connection between vitamin D (VitD) deficiency and aberrant electrocardiographic activity was investigated. We included all papers that looked at the association between VitD deficiency and electrocardiographic activity. Basic information about the research population was gathered, and the quality of the studies that were included was evaluated. Using forest plots, we determined the impact of VitD deficiency on cardiac repolarization and autonomic function. A total of 6 studies with a total of 532 participants were included in the study. VitD deficiency was found in 197 people, whereas VitD insufficiency was found in 63 people, and VitD sufficiency was found in 272. When compared to those who had sufficient VitD, VitD deficiency considerably reduced PNN50, SDANN, and RMSSD ( < 0.05), slightly lowered SDNN ( = 0.05), and lengthened TP-e ( < 0.05). Heart rate, QRS, QTc, JTc, HF, LF, and RMSDD, on the other hand, did not differ substantially between the two groups ( > 0.05). Insufficient VitD does not appear to be linked to aberrant electrocardiographic activity. VitD deficiency affects heart rate variability (HRV) and ventricular repolarization indexes compared to those with sufficient VitD. VitD insufficiency does not affect the ventricular repolarization index.
在健康人群中，异常心电图活动与心血管事件风险增加有关。研究了维生素D（VitD）缺乏与异常心电图活动之间的联系。我们纳入了所有探讨VitD缺乏与心电图活动之间关联的论文。收集了研究人群的基本信息，并评估了纳入研究的质量。使用森林图，我们确定了VitD缺乏对心脏复极化和自主神经功能的影响。该研究共纳入6项研究，总计532名参与者。发现197人存在VitD缺乏，63人存在VitD不足，272人VitD充足。与VitD充足者相比，VitD缺乏显著降低了PNN50、SDANN和RMSSD（<0.05），略微降低了SDNN（=0.05），并延长了TP-e（<0.05）。另一方面，两组之间的心率、QRS、QTc、JTc、HF、LF和RMSDD没有显著差异（>0.05）。VitD不足似乎与异常心电图活动无关。与VitD充足者相比，VitD缺乏会影响心率变异性（HRV）和心室复极化指标。VitD不足不会影响心室复极化指标。
