Nalbant Ahmet, Vatan Mehmet Bulent, Varım Perihan, Varım Ceyhun, Kaya Tezcan, Tamer Ali
Sakarya Education and Research Hospital, Internal Medicine, Adapazarı, Sakarya 54000, Turkey.
Sakarya Universitesi Tip Fakultesi, Cardiology, Sakarya 54000, Turkey.
Open Access Maced J Med Sci. 2017 Mar 22;5(2):197-200. doi: 10.3889/oamjms.2017.041. eCollection 2017 Apr 15.
This study aimed to evaluate the cardiac autonomic dysfunction and the cardiac arrhythmia risk using heart rate variability parameters in subjects with vitamin D deficiency and low cardiovascular risk.
One hundred five consecutive individuals, 54 patients with low vitamin D status and 51 healthy controls were enrolled in this study. The overall cardiac autonomic tone was quantified by using various heart rate variability parameters included mean RR interval, mean Heart Rate, mean of standard deviations of intervals for 24 hours (SDNN), standard deviation of averages of intervals (SDANN), mean of standard deviation of intervals for 5 minutes (SDNNI), root mean square of difference of successive intervals (rMSSD) and the proportion of intervals differing more than 50 ms (pNN50) values. The 12-lead ECG was recorded from each participant, and QT intervals were measured.
Baseline demographic profiles were similar between two groups. The heart rate variability parameters such as mean RR interval, mean HR, SDNN, SDANN, SDNNI, rMSSD and pNN50 (%) values were not significantly different in patients with low vitamin D status compared to control group. The electrocardiography analysis revealed only slight but significant prolongation of corrected QT (QTc) intervals in the control group.
HRV variables were not significantly altered in patients with vitamin D deficiency in low cardiovascular risk profile group. Further studies evaluating these findings in other cohorts with high cardiovascular risk are required.
本研究旨在利用心率变异性参数评估维生素D缺乏且心血管风险较低的受试者的心脏自主神经功能障碍和心律失常风险。
本研究纳入了105名连续的个体，其中54名维生素D水平较低的患者和51名健康对照者。通过使用各种心率变异性参数来量化整体心脏自主神经张力，这些参数包括平均RR间期、平均心率、24小时间期标准差的平均值（SDNN）、间期平均值的标准差（SDANN）、5分钟间期标准差的平均值（SDNNI）、连续间期差值的均方根（rMSSD）以及间期差值超过50毫秒的比例（pNN50）值。记录每位参与者的12导联心电图，并测量QT间期。
两组的基线人口统计学特征相似。与对照组相比，维生素D水平较低的患者的心率变异性参数，如平均RR间期、平均心率、SDNN、SDANN、SDNNI、rMSSD和pNN50（%）值没有显著差异。心电图分析显示，对照组仅校正QT（QTc）间期有轻微但显著的延长。
在心血管风险较低的维生素D缺乏患者中，HRV变量没有显著改变。需要在其他心血管风险较高的队列中进一步研究评估这些发现。
