Talley N J, Piper D W
Scand J Gastroenterol. 1985 Sep;20(7):896-900. doi: 10.3109/00365528509088842.
Non-ulcer dyspepsia (NUD) is defined as dyspepsia in which investigation shows no evidence of focal gastroduodenal disease or oesophagitis. The aim of the present study was to determine the proportion of NUD patients with other identifiable diseases. We interviewed 327 consecutive patients who had at least 1 month of dyspepsia before a panendoscopy that showed no evidence of oesophagitis, malignancy, or peptic ulcer. Symptoms were assessed by a structured history questionnaire. The existence of gallstones was excluded radiologically. Of the subjects studied, 75 (23%) had irritable bowel syndrome and 71 (22%) gastro-oesophageal reflux, whereas 63 (19%) had both, 25 (8%) had aerophagy, and 14 (4%) had gallstones. Of the remaining 79 patients (24%) 6 had duodenitis and 10 gastritis, whereas 1 had both. Sixty-two subjects (19%) had entirely normal endoscopic results and no ascertainable cause of their dyspepsia (termed provisionally essential dyspepsia). It is concluded that, whereas three-quarters of NUD patients have diseases that fall into other diagnostic categories, nearly one-quarter have essential dyspepsia.
非溃疡性消化不良（NUD）被定义为消化不良，经检查未发现胃十二指肠局部疾病或食管炎的证据。本研究的目的是确定患有其他可识别疾病的NUD患者的比例。我们对327例连续患者进行了访谈，这些患者在接受全面内镜检查前至少有1个月的消化不良症状，内镜检查未发现食管炎、恶性肿瘤或消化性溃疡的证据。通过结构化病史问卷对症状进行评估。通过放射学检查排除胆结石的存在。在研究的受试者中，75例（23%）患有肠易激综合征，71例（22%）患有胃食管反流，63例（19%）两者都有，25例（8%）有吞气症，14例（4%）有胆结石。在其余79例患者（24%）中，6例有十二指肠炎，10例有胃炎，1例两者都有。62名受试者（19%）的内镜检查结果完全正常，且消化不良的原因无法确定（暂称为原发性消化不良）。结论是，虽然四分之三的NUD患者患有属于其他诊断类别的疾病，但近四分之一的患者患有原发性消化不良。
