Nastaskin Igor, Mehdikhani Edgar, Conklin Jeffrey, Park Sandy, Pimentel Mark
Cedars-Sinai Medical Center, Burns and Allen Research Institute, and UCLA Geffen School of Medicine, Los Angeles, California, USA.
Dig Dis Sci. 2006 Dec;51(12):2113-20. doi: 10.1007/s10620-006-9306-y. Epub 2006 Nov 1.
Evidence points to a significant overlap between irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). In this study, we evaluate this overlap by conducting a systematic review of the literature. Six electronic databases from 1966 through January 2005 were screened by multiple search terms to identify all epidmiological evidence linking IBS and GERD. In addition, AGA meeting abstracts for 2003 and 2004 were also screened. All studies were validated by the authors and data extracted according to predefined criteria. As a separate search strategy, studies evaluating the prevalence of IBS and GERD in the general population were sought. These articles were obtained to compare the prevalence of IBS and GERD in the community to the degree of overlap. The search identified 997 original titles with 15 publications that fulfilled our eligibility criteria. Among the 15 studies, 7 determined the GERD maximum mean prevalence in patients already diagnosed with IBS to be 39.3% and the weighted mean 30.3%. The other 7 studies examined the prevalence of IBS in patients already diagnosed with GERD. The maximum mean prevalence of IBS in subjects with known GERD was 48.8% and the weighted mean 60.5%. Based on the prevalence of IBS (12.1%) and GERD (19.4%) in the community, the rate of IBS in the non-GERD community was calculated to be only 5.1%. There is a strong overlap between GERD and IBS that exceeds the individual presence of each condition. In the absence of GERD, IBS is relatively uncommon.
有证据表明肠易激综合征（IBS）和胃食管反流病（GERD）之间存在显著重叠。在本研究中，我们通过对文献进行系统综述来评估这种重叠情况。通过多个检索词对1966年至2005年1月的六个电子数据库进行筛选，以识别所有将IBS和GERD联系起来的流行病学证据。此外，还筛选了2003年和2004年美国胃肠病学会（AGA）会议的摘要。所有研究均由作者进行验证，并根据预先定义的标准提取数据。作为一种单独的检索策略，我们查找了评估普通人群中IBS和GERD患病率的研究。获取这些文章是为了将社区中IBS和GERD的患病率与重叠程度进行比较。检索共识别出997篇原始标题，其中15篇出版物符合我们的纳入标准。在这15项研究中，7项确定已确诊患有IBS的患者中GERD的最大平均患病率为39.3%，加权平均患病率为30.3%。另外7项研究调查了已确诊患有GERD的患者中IBS的患病率。已知患有GERD的受试者中IBS的最大平均患病率为48.8%，加权平均患病率为60.5%。根据社区中IBS（12.1%）和GERD（19.4%）的患病率，计算出非GERD社区中IBS的患病率仅为5.1%。GERD和IBS之间存在很强的重叠，超过了每种疾病单独出现的情况。在没有GERD的情况下，IBS相对不常见。
