慢性肾功能衰竭患者红细胞中谷胱甘肽过氧化物酶活性及还原型谷胱甘肽含量
Glutathione peroxidase activity and reduced glutathione content in erythrocytes of patients with chronic renal failure.
作者信息
Seth R K, Saini A S, Aggarwal S K
出版信息
Scand J Haematol. 1985 Aug;35(2):201-4. doi: 10.1111/j.1600-0609.1985.tb01573.x.
Abstract
Erythrocytes from 18 patients with chronic renal failure (CRF) and 10 healthy subjects were examined with respect to glutathione peroxidase (GSH-Px) activity and reduced glutathione (GSH) contents. The activity of GSH-Px and GSH content were found to be lower in RBC from CRF patients as compared with normal RBC. These reduced levels of GSH and GSH-Px in the red cells of uraemic patients may predispose the cells to oxidative damage.
摘要
对18例慢性肾衰竭（CRF）患者和10名健康受试者的红细胞进行了谷胱甘肽过氧化物酶（GSH-Px）活性和还原型谷胱甘肽（GSH）含量检测。结果发现，与正常红细胞相比，CRF患者红细胞中的GSH-Px活性和GSH含量较低。尿毒症患者红细胞中GSH和GSH-Px水平降低，可能使细胞易受氧化损伤。
Zotero 插件