基于代谢组学的冠心病研究进展与展望
Recent Advances and Perspectives of Metabolomics-Based Investigations in Coronary Heart Disease.
作者信息
Hu Jianping, Zhou Jiaxin, Liang Yong, Chen Xiaotian, Liu Hongdong, Li Bin, Huang Luqi
机构信息
Academician Workstation, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
出版信息
Curr Atheroscler Rep. 2025 Jun 9;27(1):63. doi: 10.1007/s11883-025-01304-z.
PURPOSE OF REVIEW
Coronary heart disease (CHD) is a major global threat to human health. This review summarizes the latest progress of metabolomics in CHD research, and provides insights into the pathogenesis and identify dependable biomarkers of CHD.
RECENT FINDINGS
This review has summarized 303 metabolic indicators related to CHD, with a focus on 53 biomarkers, and highlighted the top 10 biomarkers with significant clinical value. The biosynthesis of unsaturated fatty acids, amino acids, and aminoacyl-tRNA, as well as amino acid metabolism, are linked to CHD pathogenesis. Amino acids and lipids play essential roles in understanding the onset and progression of CHD. This review provides a new perspective on enhancing our understanding of CHD pathogenesis and developing effective treatment interventions.
综述目的
冠心病（CHD）是对人类健康的主要全球威胁。本综述总结了代谢组学在冠心病研究中的最新进展，并深入探讨了冠心病的发病机制，确定了可靠的生物标志物。
最新发现
本综述总结了303个与冠心病相关的代谢指标，重点关注53个生物标志物，并突出了具有显著临床价值的前10个生物标志物。不饱和脂肪酸、氨基酸和氨酰-tRNA的生物合成以及氨基酸代谢与冠心病发病机制有关。氨基酸和脂质在理解冠心病的发生和发展中起着至关重要的作用。本综述为加深我们对冠心病发病机制的理解和开发有效的治疗干预措施提供了新的视角。
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