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用于监测充血并减少心力衰竭住院次数的皮下传感器——介于深层植入式血管内监测设备和可穿戴技术之间的可行中间方案?

Subcutaneous sensors for monitoring congestion and to reduce heart failure hospitalizations-a viable middle ground between deep implantable intravascular monitoring devices and wearable technologies?

作者信息

Wetterling Friedrich, Fryc Bartlomiej, Facchi Ilaria, Okabe Toshimasa, Heist E Kevin, Fudim Marat

机构信息

Medical Circuits and Systems Laboratory, Discipline of Electronic and Electrical Engineering, Trinity College Dublin, Dublin, Ireland.

Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland.

出版信息

Heart Fail Rev. 2025 Sep;30(5):1113-1122. doi: 10.1007/s10741-025-10529-8. Epub 2025 Jun 9.

Abstract

Congestive heart failure (CHF) remains a leading cause of hospitalization and mortality worldwide. Continuous monitoring is crucial for early detection of decompensation, potentially reducing hospital admissions and improving outcomes. Cardiac implantable electronic devices (CIEDs) have been established as useful therapeutic interventions that also support continuous monitoring in order to detect early signs of decompensation. However, prior to CIED implantation, effective continuous monitoring solutions are lacking. They exist at two extremes: deep implantable intravascular solutions such as pulmonary artery pressure sensors, which are effective but costly and complex, and wearables, which are inexpensive but lack evidence of their effectiveness and depend on ongoing active patient adherence. Subcutaneous sensors may represent a promising intermediate solution-offering continuous monitoring with lower invasiveness and cost, while maintaining higher adherence compared to wearables. This review explores the role of subcutaneous sensors in CHF management, comparing existing daily trend data to deep implantable sensors measuring direct filling pressure and CIEDs for multi-parametric risk scoring. We discuss their feasibility, limitations, and future integration into routine clinical practice.

摘要

充血性心力衰竭(CHF)仍然是全球范围内住院和死亡的主要原因。持续监测对于早期发现失代偿至关重要,有可能减少住院次数并改善治疗结果。心脏植入式电子设备(CIEDs)已被确立为有用的治疗干预措施,同时也支持持续监测以检测失代偿的早期迹象。然而,在CIED植入之前,缺乏有效的持续监测解决方案。它们存在于两个极端:深度植入式血管内解决方案,如肺动脉压力传感器,有效但成本高且复杂;以及可穿戴设备,价格便宜但缺乏有效性证据,且依赖患者持续主动配合。皮下传感器可能是一种有前景的中间解决方案——提供侵入性较低和成本较低的持续监测,同时与可穿戴设备相比保持更高的配合度。本综述探讨皮下传感器在CHF管理中的作用,将现有的每日趋势数据与测量直接充盈压的深度植入式传感器以及用于多参数风险评分的CIEDs进行比较。我们讨论了它们的可行性、局限性以及未来融入常规临床实践的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/12296957/931b11c551f9/10741_2025_10529_Fig1_HTML.jpg

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