Doutremépuich C, Toulemonde F, Lormeau J C
Semin Thromb Hemost. 1985 Jul;11(3):323-5. doi: 10.1055/s-2007-1004386.
A number of studies, including our own, have demonstrated that heparin was not absorbed when administered directly in solution by the oral route. We have attempted to enhance the absorption of orally administered heparin by applying three different approaches: the use of heparin fractions of various molecular weights lower than 6000 D, the complexation of one fraction with glycine (to adjust the ionization of the drug), and the use of gastroresistant capsules administered directly into the stomach. None of these measures resulted in significantly increased absorption, although large doses were administered (15,000 anti-Xa U/kg). New studies will therefore be necessary if heparin and its fractions are to be provided with a satisfactory capacity to be absorbed.
包括我们自己的研究在内，许多研究都表明，口服直接给予肝素溶液时，肝素不会被吸收。我们尝试了三种不同的方法来提高口服肝素的吸收：使用分子量低于6000 D的各种肝素级分、将一种级分与甘氨酸络合（以调节药物的离子化）以及使用直接送入胃内的肠溶胶囊。尽管给予了大剂量（15,000抗Xa单位/千克），但这些措施均未导致吸收显著增加。因此，如果要使肝素及其级分具有令人满意的吸收能力，就需要进行新的研究。
