Doutremépuich C, Masse A, Oca C, Maury M O, Gestreau J L, Toulemonde F, Lormeau J C
Pathol Biol (Paris). 1984 Jan;32(1):45-8.
Commercial heparin cannot practically cross the intestinal barrier. Meanwhile, because of the theoretical interest in oral heparin therapeutics, we applied our studies to a low molecular weight heparin fraction (3 000 to 4 000 D). This fraction was directly injected into anaesthetized rabbit duodenum. For an equal anticoagulant activity (expressed in international units), commercial heparin is not absorbed whereas the low molecular weight fraction mainly induces an early plasmatic anti-Xa activity which remains over the fifth hour.
市售肝素实际上无法穿过肠道屏障。同时，鉴于口服肝素疗法在理论上具有研究价值，我们将研究应用于一种低分子量肝素组分（3000至4000道尔顿）。该组分直接注射到麻醉兔的十二指肠中。对于同等抗凝活性（以国际单位表示），市售肝素不被吸收，而低分子量组分主要诱导早期血浆抗Xa活性，该活性在第五小时后仍持续存在。
