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更年期与身体成分:一个复杂的领域。

Menopause and Body Composition: A Complex Field.

作者信息

Juppi Hanna-Kaarina, Karppinen Jari E, Laakkonen Eija K

机构信息

Finnish Hub for Development and Validation of Integrated Approaches, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

出版信息

Semin Reprod Med. 2025 Jun 9. doi: 10.1055/s-0045-1809531.

Abstract

Given that menopause affects about half of the world's midlife population, it is crucial to understand its impact beyond traditional menopausal symptomology. For instance, many women, while transitioning through menopause, experience profound changes in body composition. These changes may contribute to postmenopausal reductions in metabolic health. This narrative review explores the influence of menopause on skeletal muscle and adipose tissue, highlighting the decline in muscle mass and strength and the gain and redistribution of adipose tissue, particularly the increase in visceral adiposity. Although menopausal changes in body composition are seemingly extensively studied, the longitudinal studies are not that common, and the precise mechanisms driving body composition changes remain unclear, with uncertainties surrounding the roles of hormonal shifts compared with regular aging, energy balance, and lifestyle factors. Notably, it remains debated whether menopause or estrogen meaningfully influences resting energy expenditure. The review also considers the potential mitigating effects of menopausal hormone therapy and regular exercise. Understanding these changes is essential for developing effective strategies to support women's health during and after menopause.

摘要

鉴于更年期影响着全球约一半的中年人口,了解其在传统更年期症状之外的影响至关重要。例如,许多女性在经历更年期过渡时,身体成分会发生深刻变化。这些变化可能导致绝经后代谢健康的下降。这篇叙述性综述探讨了更年期对骨骼肌和脂肪组织的影响,强调了肌肉质量和力量的下降以及脂肪组织的增加和重新分布,特别是内脏脂肪的增加。尽管更年期身体成分的变化似乎已得到广泛研究,但纵向研究并不常见,驱动身体成分变化的精确机制仍不清楚,与正常衰老、能量平衡和生活方式因素相比,激素变化所起的作用存在不确定性。值得注意的是,更年期或雌激素是否对静息能量消耗有显著影响仍存在争议。该综述还考虑了更年期激素治疗和定期锻炼的潜在缓解作用。了解这些变化对于制定有效的策略以支持女性在更年期期间及之后的健康至关重要。

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