Mojić Marija, Radulović Nataša, Bobić Simonida, Radenković Sandra, Cruz-Adalia Aránzazu, Stojanović Ivana
Department of Immunology, Institute for Biological Research "Siniša Stanković" - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Department for Medical Oncology, Institute for Oncology and Radiology, Belgrade, Serbia.
Immunol Lett. 2025 Dec;276:107051. doi: 10.1016/j.imlet.2025.107051. Epub 2025 Jun 7.
Innate lymphoid cells (ILC) play a crucial role in shaping immune responses and maintaining tissue homeostasis. Recent research has identified their involvement in breast cancer pathogenesis, mainly through shaping the tumor microenvironment, where they can exert dual roles, either promoting tumor eradication by enhancing anti-tumor immunity, or facilitating tumor progression through mechanisms of immune evasion. This functional plasticity makes ILC attractive targets for immunotherapy. Furthermore, their slow proliferation enables them to survive anti-proliferative radiation therapy and chemotherapy, which may support continuous immune surveillance of breast cancer tissue. However, this same resilience poses a significant challenge, as surviving ILC could contribute to tumor persistence or recurrence. Additionally, anti-estrogen therapy, chemotherapy and immune checkpoint inhibitors, commonly used in breast cancer treatment, may interfere with ILC function, either dampening their anti-tumor potential or enhancing their pro-tumor activities. Understanding the complex interactions between ILC and conventional therapies is critical for designing effective immunotherapeutic approaches that include ILC targeting, potentially overcoming resistance and improving patient outcomes in breast cancer therapy.
固有淋巴细胞（ILC）在塑造免疫反应和维持组织稳态中发挥着关键作用。最近的研究已经确定它们参与乳腺癌的发病机制，主要是通过塑造肿瘤微环境，在其中它们可以发挥双重作用，要么通过增强抗肿瘤免疫促进肿瘤根除，要么通过免疫逃避机制促进肿瘤进展。这种功能可塑性使ILC成为免疫治疗的有吸引力的靶点。此外，它们的缓慢增殖使它们能够在抗增殖放疗和化疗中存活下来，这可能支持对乳腺癌组织的持续免疫监视。然而，同样的恢复力也带来了重大挑战，因为存活下来的ILC可能导致肿瘤持续存在或复发。此外，乳腺癌治疗中常用的抗雌激素疗法、化疗和免疫检查点抑制剂可能会干扰ILC功能，要么抑制它们的抗肿瘤潜力，要么增强它们的促肿瘤活性。了解ILC与传统疗法之间的复杂相互作用对于设计有效的免疫治疗方法至关重要，这些方法包括靶向ILC，有可能克服耐药性并改善乳腺癌治疗的患者预后。
