Tomoto Tsubasa, Kumagai Hiroshi, Tarumi Takashi, Sugawara Jun
Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Integrated Research Center for Self-Care Technology, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Am J Physiol Regul Integr Comp Physiol. 2025 Jul 1;329(1):R204-R215. doi: 10.1152/ajpregu.00038.2025. Epub 2025 Jun 9.
Aortic compliance reflects the ability to buffer arterial pulsations generated by the left ventricle (LV) and attenuate pulsatile cerebral blood flow (CBF). Endurance training is associated with increased stroke volume (SV) and enhanced LV systolic function, potentially increasing arterial pulsations to the brain. This study investigated the contribution of aortic compliance to the heart-brain hemodynamic interaction, providing insights from endurance training intervention and lower body negative pressure (LBNP) stimulus. Ten male collegiate tennis players underwent an 8-mo endurance training program to improve cardiac function. SV and LV systolic functions were measured using echocardiography and applanation tonometry. Pulsatile cerebral blood velocity in the middle cerebral artery was assessed by transcranial Doppler. Aortic compliance was calculated as the ratio between estimated SV via Modelflow and aortic pulse pressure via transfer function from radial arterial pressure. The release of -30 mmHg LBNP was used to initiate a rapid recovery of limited venous return and consequent increases in SV and CBF to assess dynamic recovery slopes. Endurance training increased SV, LV systolic function, and aortic compliance at rest, whereas pulsatile CBF was unchanged. The recovery slopes of SV and aortic compliance were steeper after endurance training, whereas the slopes of pulsatile CBF remained similar. The change in the slope of aortic compliance was negatively correlated with the change in the slope of pulsatile CBF ( = -0.758, = 0.011). These results suggest that improved aortic compliance after endurance training may accommodate increased SV and LV systolic function and buffer potential increases in arterial pulsations to the brain. Eight months of progressive moderate-to-vigorous endurance training increased stroke volume (SV), left ventricular (LV) systolic performance, and aortic compliance, whereas pulsatile cerebral blood flow (CBF) remained unchanged in young, healthy men. The increase in aortic compliance was associated with decreased pulsatile CBF. These findings suggest that the improved aortic compliance after endurance training may offset the expected increases in pulsatile CBF induced by the increased SV and enhanced LV systolic function.
主动脉顺应性反映了缓冲左心室（LV）产生的动脉搏动以及减弱搏动性脑血流量（CBF）的能力。耐力训练与每搏输出量（SV）增加和左心室收缩功能增强有关，这可能会增加流向大脑的动脉搏动。本研究调查了主动脉顺应性对心脑血流动力学相互作用的贡献，通过耐力训练干预和下体负压（LBNP）刺激提供见解。十名男性大学网球运动员接受了为期8个月的耐力训练计划以改善心脏功能。使用超声心动图和压平式眼压计测量SV和左心室收缩功能。通过经颅多普勒评估大脑中动脉的搏动性脑血流速度。主动脉顺应性计算为通过Modelflow估计的SV与通过桡动脉压力的传递函数得到的主动脉脉压之间的比值。释放-30 mmHg的LBNP用于启动有限静脉回流的快速恢复以及随之而来的SV和CBF增加，以评估动态恢复斜率。耐力训练使静息时的SV、左心室收缩功能和主动脉顺应性增加，而搏动性CBF保持不变。耐力训练后SV和主动脉顺应性的恢复斜率更陡，而搏动性CBF的斜率保持相似。主动脉顺应性斜率的变化与搏动性CBF斜率的变化呈负相关（r = -0.758，P = 0.011）。这些结果表明，耐力训练后主动脉顺应性的改善可能适应增加的SV和左心室收缩功能，并缓冲流向大脑的动脉搏动的潜在增加。八个月的渐进性中度至剧烈耐力训练增加了每搏输出量（SV）、左心室（LV）收缩性能和主动脉顺应性，而年轻健康男性的搏动性脑血流量（CBF）保持不变。主动脉顺应性的增加与搏动性CBF的减少有关。这些发现表明，耐力训练后主动脉顺应性的改善可能抵消由增加的SV和增强的左心室收缩功能引起的搏动性CBF的预期增加。
