Lawler Nathan G, Yonker Lael M, Lodge Samantha, Nitschke Philipp, Leonard Maureen M, Gray Nicola, Whiley Luke, Masuda Reika, Holmes Elaine, Wist Julien, Fasano Alessio, Nicholson Jeremy K
Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Department of Pediatrics, Massachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, Massachusetts 02114, United States.
J Proteome Res. 2025 Jul 4;24(7):3470-3483. doi: 10.1021/acs.jproteome.5c00062. Epub 2025 Jun 9.
SARS-CoV-2 infections in children lead to symptoms from mild respiratory illness to severe postacute sequelae of COVID-19, including multisystem inflammatory syndrome in Children (MIS-C). We conducted a metabolic profiling of 147 children's serum samples, including acute COVID-19 patients, MIS-C patients, and healthy controls. Using nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry, we measured 1101 metabolites. The results revealed distinct metabolic profiles in acute COVID-19 and MIS-C patients, with significant alterations in lipid classes. Both conditions exhibited an elevated Apo-B100/Apo-A1 ratio and increased serum inflammatory markers. MIS-C patients showed unique disruptions, including increased triglycerides and altered lipoprotein composition. Despite milder clinical respiratory symptoms, children's metabolic disturbances mirrored those seen in severe adult COVID-19 patients, indicating a shared inflammatory response to SARS-CoV-2. This suggests potential long-term health impacts, underscoring the need for continued research into the metabolic consequences of COVID-19 in children.
儿童感染新型冠状病毒2型（SARS-CoV-2）会导致从轻度呼吸道疾病到新冠病毒病严重急性后遗症等一系列症状，包括儿童多系统炎症综合征（MIS-C）。我们对147名儿童的血清样本进行了代谢谱分析，样本包括新冠病毒病急性期患者、MIS-C患者和健康对照。我们使用核磁共振波谱法和液相色谱-质谱联用技术测定了1101种代谢物。结果显示，新冠病毒病急性期患者和MIS-C患者具有不同的代谢谱，脂质类别有显著变化。两种情况均表现出载脂蛋白B100/载脂蛋白A1比值升高和血清炎症标志物增加。MIS-C患者表现出独特的代谢紊乱，包括甘油三酯升高和脂蛋白组成改变。尽管儿童临床呼吸道症状较轻，但其代谢紊乱情况与成年新冠病毒病重症患者相似，这表明对SARS-CoV-2存在共同的炎症反应。这提示可能存在潜在的长期健康影响，凸显了继续研究新冠病毒病对儿童代谢影响的必要性。
