Luo Yunyan, Chi Anmin, Guo Xuehong, Song Juhui, Zhang Xiuxiu, Dong Yangting, Wang Chanjuan, Zhang Ting, Deng Jie, Ma Jinhao, Li Xueshuang, Shan Keren, Guan Zhizhong, He Yan
Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, & Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co. Constructed By the Province and Ministry, Guizhou Medical University, Guiyang, Guizhou, China.
Department of Laboratory Medicine, Xingyi People's Hospital, Guizhou, China.
BMC Ecol Evol. 2025 Jun 9;25(1):61. doi: 10.1186/s12862-025-02400-z.
Y-STR genotyping can be used to predict the genetic mixed landscape of different populations effectively. In this study, 25 Y-STR loci were detected in 745 unrelated healthy males from the Bai, Bouyei, Dong, Gelao, Hui, Maonan, Mulao, Shui, Tujia, Yi and Han groups in Guizhou Province via a Y27Plex fluorescence detection kit. The results revealed that the kit had high gene diversity (GD: 0.0878 ~ 0.9581; HD: 0.9781 ~ 0.9987). The genetic distance ranged from 0.0172-0.3750. On the basis of PCA, phylogenetic tree and structure analysis, the same language groups tended to show closer genetic relationships among the 11 sample populations. According to the genetic relationship analysis of the 11 samples and 22 reference populations, the genetic relationships of Guizhou Han and Guangxi Gin were the closest (0.018), whereas those of the Tujia and She nationalities were the farthest in Guizhou (0.4483). Additionally, Guizhou Tujia, Guizhou Hui, Xinjiang Mongolians, Yunnan Lahu, Kazakh Uzbekistan and Kazakhstan were clustered together. This study provides a reference for the genetic structure and genetic differentiation of 11 indigenous populations in Guizhou Province and provides useful paternal information for population genetics, archaeology and historical research.
Y染色体短串联重复序列（Y-STR）基因分型可有效用于预测不同人群的遗传混合格局。本研究采用Y27Plex荧光检测试剂盒，对贵州省白族、布依族、侗族、仡佬族、回族、毛南族、仫佬族、水族、土家族、彝族和汉族745名无血缘关系的健康男性进行了25个Y-STR基因座的检测。结果显示，该试剂盒具有较高的基因多样性（GD：0.0878 ~ 0.9581；HD：0.9781 ~ 0.9987）。遗传距离范围为0.0172 - 0.3750。基于主成分分析（PCA）、系统发育树和结构分析，在11个样本群体中，同一语系群体往往显示出更密切的遗传关系。根据对11个样本与22个参考群体的遗传关系分析，贵州汉族与广西京族的遗传关系最密切（0.018），而土家族与畲族在贵州的遗传关系最远（0.4483）。此外，贵州土家族、贵州回族、新疆蒙古族、云南拉祜族、哈萨克斯坦乌兹别克族和哈萨克族聚为一类。本研究为贵州省11个世居民族的遗传结构和遗传分化提供了参考，为群体遗传学、考古学和历史研究提供了有用的父系信息。
