• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Targeting enabled homolog with daunorubicin inhibits ERK1/2/c-Fos pathway and suppresses hepatocellular carcinoma progression.

作者信息

Li Zhi-Mei, Liu Guan, Liu Qing-Qing, You Wei-Ming, Zhao Ming-Gao

机构信息

Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, China.

Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

出版信息

Clin Transl Med. 2025 Jun;15(6):e70366. doi: 10.1002/ctm2.70366.

DOI:10.1002/ctm2.70366
PMID:40490956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12148948/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ec/12148948/7abc73bc631f/CTM2-15-e70366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ec/12148948/88b338accdee/CTM2-15-e70366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ec/12148948/14963ac77270/CTM2-15-e70366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ec/12148948/7abc73bc631f/CTM2-15-e70366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ec/12148948/88b338accdee/CTM2-15-e70366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ec/12148948/14963ac77270/CTM2-15-e70366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ec/12148948/7abc73bc631f/CTM2-15-e70366-g001.jpg

相似文献

1
Targeting enabled homolog with daunorubicin inhibits ERK1/2/c-Fos pathway and suppresses hepatocellular carcinoma progression.用柔红霉素靶向 Enabled 同源物可抑制 ERK1/2/c-Fos 通路并抑制肝细胞癌进展。
Clin Transl Med. 2025 Jun;15(6):e70366. doi: 10.1002/ctm2.70366.
2
MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma.MTBP抑制肝细胞癌中的Erk1/2-Elk-1信号通路。
Oncotarget. 2018 Apr 20;9(30):21429-21443. doi: 10.18632/oncotarget.25117.
3
MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma.miRNA-26a 是一个关键的调控因子，可抑制 c-Myc/EZH2 双高的晚期肝癌的进展和转移。
Cancer Lett. 2018 Jul 10;426:98-108. doi: 10.1016/j.canlet.2018.04.005. Epub 2018 Apr 11.
4
Oleanolic acid inhibits hypoxic tumor-derived exosomes-induced premetastatic niche formation in hepatocellular carcinoma by targeting ERK1/2-NFκB signaling.齐墩果酸通过靶向ERK1/2-NFκB信号通路抑制缺氧肿瘤来源的外泌体诱导的肝细胞癌前转移微环境形成。
Phytomedicine. 2024 Apr;126:155208. doi: 10.1016/j.phymed.2023.155208. Epub 2023 Nov 11.
5
Folate receptor alpha is associated with cervical carcinogenesis and regulates cervical cancer cells growth by activating ERK1/2/c-Fos/c-Jun.叶酸受体α与宫颈癌发生相关，并通过激活ERK1/2/c-Fos/c-Jun调节宫颈癌细胞生长。
Biochem Biophys Res Commun. 2017 Sep 30;491(4):1083-1091. doi: 10.1016/j.bbrc.2017.08.015. Epub 2017 Aug 3.
6
Calmodulin/CaMKII-γ mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway.钙调蛋白/CaMKII-γ 通过 ERK1/2/CREB/c-fos 信号通路介导阿帕替尼耐药肝癌细胞的存活能力。
J Cell Biochem. 2021 Jun;122(6):612-625. doi: 10.1002/jcb.29892. Epub 2021 Jan 18.
7
Rap2B knockdown suppresses malignant progression of hepatocellular carcinoma by inactivating the PTEN/PI3K/Akt and ERK1/2 pathways.Rap2B 敲低通过使 PTEN/PI3K/Akt 和 ERK1/2 通路失活来抑制肝癌的恶性进展。
Mol Cell Biochem. 2020 Mar;466(1-2):55-63. doi: 10.1007/s11010-020-03687-w. Epub 2020 Feb 12.
8
Jun/Fos promotes migration and invasion of hepatocellular carcinoma cells by enhancing BORIS promoter activity.Jun/Fos 通过增强 BORIS 启动子活性促进肝癌细胞的迁移和侵袭。
Int J Biochem Cell Biol. 2024 Apr;169:106540. doi: 10.1016/j.biocel.2024.106540. Epub 2024 Jan 26.
9
[miR-324-5p inhibits lipopolysaccharide-induced proliferation of rat glomerular mesangial cells by regulating the Syk/Ras/c-fos pathway].[微小RNA-324-5p通过调控脾酪氨酸激酶/大鼠肉瘤病毒/原癌基因c-fos途径抑制脂多糖诱导的大鼠肾小球系膜细胞增殖]
Nan Fang Yi Ke Da Xue Xue Bao. 2020 Nov 30;40(11):1571-1578. doi: 10.12122/j.issn.1673-4254.2020.11.06.
10
ERK1/2, but not ERK5, is necessary and sufficient for phosphorylation and activation of c-Fos.细胞外信号调节激酶1/2（ERK1/2）而非ERK5，对于c-Fos的磷酸化和激活是必需且充分的。
Cell Signal. 2009 Jun;21(6):969-77. doi: 10.1016/j.cellsig.2009.02.006. Epub 2009 Feb 25.

本文引用的文献

1
The development of α, β-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK/c-Fos/Jun pathway.
Eur J Med Chem. 2025 Mar 15;286:117291. doi: 10.1016/j.ejmech.2025.117291. Epub 2025 Jan 19.
2
The Role of Vasodilator-stimulated Phosphoproteins in the Development of Malignant Tumors.血管扩张刺激磷蛋白在恶性肿瘤发展中的作用。
Curr Cancer Drug Targets. 2024;24(5):477-489. doi: 10.2174/0115680096262439231023110106.
3
Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway.RNA 结合蛋白剪接因子 3b 亚基 4（SF3B4）调控的同源物（ENAH）通过 Notch 信号通路加剧肝癌细胞的增殖、侵袭和迁移。
Bioengineered. 2022 Feb;13(2):2194-2206. doi: 10.1080/21655979.2021.2023983.
4
The role of ARHGAP9: clinical implication and potential function in acute myeloid leukemia.ARHGAP9 的作用：在急性髓系白血病中的临床意义和潜在功能。
J Transl Med. 2021 Feb 12;19(1):65. doi: 10.1186/s12967-021-02733-5.
5
The actin modulator hMENA regulates GAS6-AXL axis and pro-tumor cancer/stromal cell cooperation.肌动蛋白调节剂 hMENA 调节 GAS6-AXL 轴和促肿瘤癌/基质细胞合作。
EMBO Rep. 2020 Nov 5;21(11):e50078. doi: 10.15252/embr.202050078. Epub 2020 Sep 10.
6
A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.一种用于抑制富含脯氨酸基序介导的蛋白质-蛋白质相互作用的模块化工具包。
Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5011-6. doi: 10.1073/pnas.1422054112. Epub 2015 Apr 6.
7
Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines.人Mena（ENAH）及其剪接变体hMena+11a的分子克隆：表皮生长因子增加它们在乳腺癌细胞系中的表达并刺激hMena+11a磷酸化。
Cancer Res. 2007 Mar 15;67(6):2657-65. doi: 10.1158/0008-5472.CAN-06-1997.
8
Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma.丝裂原活化蛋白激酶/细胞外信号调节激酶在人肝细胞癌中的激活
Hepatology. 1998 Apr;27(4):951-8. doi: 10.1002/hep.510270409.