Olkowski Z L, McLaren J R, Wilkins S A, Maruszczak A J, Kirchner A B
AJR Am J Roentgenol. 1977 May;128(5):839-42. doi: 10.2214/ajr.128.5.839.
A total of 126 individuals were tested for circulating T lymphocyte levels: 10 patients with stage I-III squamous cell carcinoma of the cervix before treatment; 65 women previously treated with radiation for stage I and II squamous cell carcinoma of the cervix; and 51 healthy age-matched controls. Percentages of aneuploid cells and DNA content in vaginal or cervical smears were determined in 94 patients. All patients with squamous cell carcinoma of the cervix had lower ratios and levels of circulating T lymphocytes than healthy controls. Cytologic and cytochemical DNA studies of vaginal and cervical smears revealed that these individuals had high percentages of aneuploid cells in cervical smears as well as high DNA values. Patients with no evidence of dysplasia had increased circulating T lymphocyte levels compared to pretreatment values, a lower number of aneuploid cells, and mean DNA values close to diploid cells. Based on cytologic and quantitative DNA studies of vaginal and cervical smears, postirradiation dysplasia was diagnosed in 17 of 65 women previously treated by radiation for squamous cell carcinoma of the cervix. No difference in the levels of circulating T lymphocytes between women with postirradiation dysplasia and women without this mucosal disorder and no evidence of cancer was found.
共有126人接受了循环T淋巴细胞水平检测：10例I - III期宫颈鳞状细胞癌患者在治疗前；65例曾因I期和II期宫颈鳞状细胞癌接受放疗的女性；以及51名年龄匹配的健康对照者。对94例患者的阴道或宫颈涂片进行了非整倍体细胞百分比和DNA含量测定。所有宫颈鳞状细胞癌患者的循环T淋巴细胞比例和水平均低于健康对照者。阴道和宫颈涂片的细胞学和细胞化学DNA研究显示，这些个体的宫颈涂片中非整倍体细胞百分比高，且DNA值高。与治疗前相比，无发育异常迹象的患者循环T淋巴细胞水平升高，非整倍体细胞数量减少，平均DNA值接近二倍体细胞。根据阴道和宫颈涂片的细胞学和定量DNA研究，65例曾因宫颈鳞状细胞癌接受放疗的女性中有17例被诊断为放疗后发育异常。放疗后发育异常的女性与无这种黏膜疾病且无癌症迹象的女性之间，循环T淋巴细胞水平没有差异。
